(C) 2009 Elsevier Ltd. All rights reserved.”
“Polychlorinated biphenyls (PCBs) and their metabolites are environmental chemical contaminants which can produce reactive NVP-LDE225 oxygen species (ROS) by auto-oxidation of di-hydroxy PCBs as well as the reduction of quinones and redox-cycling. We investigate the hypothesis that 2-(4-chlorophenyl)benzo-1,4-quinone (4-Cl-BQ), a metabolite of 4-chlorobiphenyl (PCB3), induced ROS-signaling inhibits cellular proliferation. Monolayer cultures of exponentially growing asynchronous human non-malignant prostate epithelial cells (RWPE-1) were incubated with 0-6 mu M of 4-Cl-BQ and harvested at the end of 72 h of incubation

to assess antioxidant enzyme expression, cellular ROS GW4869 order levels, cell growth, and cell cycle phase distributions. 4-Cl-BQ decreased manganese superoxide dismutase (MnSOD) activity, protein, and mRNA levels. 4-Cl-BQ treatment increased dihydroethidium (DHE) fluorescence, which

was suppressed in cells pretreated with polyethylene glycol conjugated superoxide dismutase (PEG-SOD). The increase in ROS levels was associated with a decrease in cell growth, and an increase in the percentage of S-phase cells. These effects were suppressed in cells pretreated with PEG-SOD. 4-Cl-BQ treatment did not change the protein levels of phosphorylated H2AX at the end of 72 h of incubation, suggesting that the inhibition in cell growth and accumulation of cells in S-phase learn more at the end of the treatments were probably not due to 4-Cl-BQ induced DNA double strand break. These results demonstrate that MnSOD activity and ROS-signaling perturb proliferation in 4-Cl-BQ treated in vitro cultures of human prostate cells. (C) 2010 Elsevier Ltd. All rights reserved.”
“During the

last 20 years, there has been a shift away from combined heart-lung transplantation (HLT) in favor of bilateral lung transplantation. This paradigm shift allowed for the donor heart to be transplanted to another patient. However, HLT remains to be the definitive surgical treatment for certain congenital heart disorders and Eisenmenger’s syndrome. With a growing population of adult patients with congenital heart disease, there remains a need for HLT. This article provides a perspective on the past and the future of HLT.”
“Polychlorinated biphenyls (PCBs) are widespread environmental contaminants, and co-planar PCBs can induce oxidative stress and activation of pro-inflammatory signaling cascades which are associated with atherosclerosis. The majority of the toxicological effects elicited by the co-planar PCB exposure are associated to the activation of the aryl hydrocarbon receptor (AHR) and subsequent induction of responsive genes.

In health studies among older people, SRH captures not only social and physical health but also broader economic well-being.”
“PURPOSE: To estimate the incidence of acute-onset endophthalmitis

after cataract surgery and to report its clinical features, microbiology, and final visual outcomes.

SETTING: King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia.

METHODS: This was a retrospective observational case series.

RESULTS: The 10-year incidence 4SC-202 of acute-onset endophthalmitis after cataract surgery was 0.068%: 0.049% for extracapsular cataract extraction (ECCE) and 0.085% for clear corneal phacoemulsification (P = .268). The incidence of endophthalmitis was 0.053% during the first 5 years of the study and 0.08% during the next 5 years. The most common presenting features were pain and poor red reflex. Of the 20 cases, 18 were culture positive. The culture isolates showed Staphylococcus species in 7 eyes (35%), Streptococcus species in 7 eyes (35%), polymicrobial or mixed infections in 3 eyes (15%), and Propionibacterium acnes in 1 eye (5%). Two patients (10%) achieved a final visual acuity of 20/40 or better, 5 (25%) had worse than 20/40 to better than 20/200, and 8 (40%) had worse than 20/200; 5 eyes (25%) were eviscerated. Visual outcomes were good in endophthalmitis cases after phacoemulsification and in cases caused by Staphylococcus epidermidis

and selleckchem worse in cases that Galardin had Streptococcus species endophthalmitis.

CONCLUSIONS: Clear corneal phacoemulsification had a 1.73-fold higher risk for acute endophthalmitis than ECCE. Although the incidence of endophthalmitis

after ECCE was lower than after phacoemulsification, the outcome was much worse in post-ECCE endophthalmitis cases. Poor visual outcomes were associated with more virulent organisms and delayed presentation.”
“Highly reactive alpha,beta-unsaturated aldehydes like 4-hydroxy-2-nonenal (4-HNE), generated from oxidation of polyunsaturated fatty acids, can bind to proteins, polynucleotides and exert cytotoxicity. 4-HNE is known to react readily with thiol and amino groups on free or bound amino acids. Recently, hydrogen sulfide (H(2)S) has been identified as an endogenous vascular gasotransmitter and neuromodulator which can reach up to 160 mu mol/l in the brain. Markedly higher 4-HNE concentrations were reported in the brain of patients suffering from Alzheimer’s disease. Assuming that the low molecular thiol H(2)S may react with 4-HNE, we have tested the ability of H(2)S to counteract the cytotoxic and protein-modifying activity of 4-HNE. The results show that H(2)S at physiologically relevant concentrations could effectively protect neuronal cells (SH-SY5Y) from the cytotoxic action of 4-HNE. The HNE-modification of cellular proteins was also inhibited in presence of H(2)S.

Deficits are revealed in the management this website of spinal trauma (34-48% competence in senior trainees) and spinal conditions requiring the use of implants and anterior approaches, with the exception of anterior cervical stabilisation.

European neurosurgical trainees possess incomplete competence in dealing with spinal disorders. EANS trainees advocate the development of a postresidency spine subspecialty training program.”
“Ruptured uterus is an obstetric catastrophe and results in significant maternal and perinatal morbidity and mortality in Nigeria.

To review the incidence and management of ruptured uterus over the 8-year period (2000-2004 and 2007-2009)

and analysis of records of cases of ruptured uterus during the period under review in a descriptive study.

The incidence of uterine rupture is 1 in 81 deliveries with

a contribution of 13.8% to maternal mortality in Ebonyi State University Teaching Hospital, Nigeria. There was high fetal wastage as 99 (97.1%) of the babies died. The highest incidence of ruptured uterus was found in the para 2-4 group. Teenagers constituted 4 (3.96%) of the cases. Majority of the rupture, 69 (65.4%) occurred anteriorly. Fifty-seven LDC000067 (56.4%) had only repair of the rupture done. The greatest complication was septicemia, which occurred in 32 (31.7%) of the patients.

The incidence of uterine rupture is very high in our center. It is one of the highest causes of maternal and perinatal morbidity and mortality. There should be a multi-pronged

effort aimed at improving the utilization of medical services by the populace and the health institutions offering efficient obstetric emergency care.”
“A convenient approach has been developed for the preparation of microsize hydrogels composed of crosslinked poly(acrylic acid) (PAA) and poly(N-isopropylacrylamide) (PNIPAm). First, semi-interpenetration polymer networks of hydropropylcellulose (HPC) and PNIPAm-co-PAA copolymer are formed through the copolymerization and crosslinking of monomer acrylic acid and N-isopropylacrylamide in HPC aqueous solution. After the selective removal of HPC from networks Dinaciclib due to ionization of PAA units and disruption of hydrogen bonding with increasing pH, PNIPAm-co-PAA microgels are obtained, whose volume is confirmed to be responsive to both temperature and pH. Doxorubicin hydrochloride (Dox) can be encapsulated in PNIPAm-co-PAA microgels with high drug loading driven by the electrostatic interaction, and a sustained-release characteristic of Dox from the microgels is observed under physiological pH value and temperature. In vitro cell experiments, the drug-loaded microgels can be taken up by LoVo cells and release their payload in cell cytoplasm without loss of drug efficacy.

Network polymers with this crosslinked reagent, methacrylic

acid, and silyl monomers of 2-hydroxyethyl methacrylate ester were synthesized and studied their properties. These sily monomers are: 2-[(triethylsilyl)oxy] ethyl methacrylate, 2-((tert-butyldimethylsilyl) oxy) ethyl methacrylate, and 2-((triphenylsilyl) oxy) ethyl methacrylate. All monomers and polymers were identified by spectroscopic methods. Then mesalasine was entrapped in these network polymers and the in vitro release profiles were established separately in both enzyme-free simulated gastric and intestinal fluids (SGF, pH 1) and (SIF, pH 7.4), respectively. In vitro release studies showed that these network polymers can be good candidates for colon-specific drug delivery. (C) 2011 Wiley Periodicals, Inc. J Appl Polym Sci 122: 2368-2373, 2011″
“The PCI-32765 mw role of dietary and other lifestyle factors in colorectal cancer recurrence and survival is largely unknown. We conducted a review to summarize the evidence from epidemiologic

studies that examined the association of body mass index (BMI), physical activity, and nutrition with colorectal cancer recurrence and survival. We searched MEDLINE and EMBASE for relevant epidemiologic studies published up to March 2010 by using MeSH terms and related key words. We identified 36 articles that were based on 31 independent studies on BMI (n = 21), physical activity (n = 6), or nutrition (n = 12) in relation to DMH1 mw colorectal cancer recurrence and survival. Studies were generally based on follow-up of cases in existing patient series, case-control or cohort studies, or chemotherapy trials. BMI, physical activity, and nutrition mostly referred to the time at or before diagnosis. Only 10 studies assessed BMI (n = 1), physical activity (n = 4), or nutrition (n = 5) after diagnosis. There may be an association between higher BMI and body fatness before or at the time of diagnosis MLN4924 clinical trial and a higher all-cause mortality or colorectal

cancer specific mortality or recurrence, although results may differ by sex, tumor location, and molecular subtype. There may be a relation between higher leisure-time physical activity after diagnosis and a lower all-cause or colorectal cancer specific mortality. For dietary factors, statistically significant associations were only shown for single foods, nutrients, and dietary patterns in single studies. In conclusion, only a paucity of data is available on the effect of dietary and other lifestyle factors on colorectal cancer recurrence and survival. Thus far, no clear conclusions can be drawn. Future studies are warranted, particularly on postdiagnosis BMI and diet. Am J Clin Nutr 2010;92:471-90.”
“Background: At the verge of elimination of malaria in Bhutan, this study was carried out to analyse the trend of malaria in the endemic districts of Bhutan and to identify malaria clusters at the sub-districts. The findings would aid in implementing the control activities.

Five amines were found in the fruits (spermidine, spermine, putrescine, serotonin and agmatine). Total amines levels varied from 0.77 mg/100

g in mango up to 7.53 mg/100 g in passion fruit. Spermidine was detected in every fruit whereas putrescine and spermine were found in most of them. Agmatine was detected in some samples of pineapple, papaya and passion fruit and serotonin was present in pineapple and passion fruit. Passion fruit is a good source of the polyamines spermidine and spermine (3.05 and 2.43 mg/100 g. respectively) and, therefore, could play an important role in growth, health, antioxidant activity and membrane permeability. Papaya is a good source of serotonin (0.99 mg/100 g), which has been associated with IPI-145 inhibitor enabling the gut to mediate reflex activity and also with decreasing the risk of thrombosis. Histamine, a peripheral vasodilator, and the vasoconstrictors tyramine, tryptamine and phenylethylamine, as well as cadaverine check details were not detected in any of the fruits analyzed. Due to the diversity of amines in these fruits, they can provide different functional properties and, therefore, can be used for different nutritional needs. (C) 2010 Elsevier Ltd. All rights reserved.”
“Objective: The aim of our study was to retrospectively analyze surgical complications arising from the collocation of suburethral

mesh in the lower urinary tract, using both the transobturator and retropubic methods. Patients and Methods: During the period between November 2002 and June 2011, we retrospectively studied 190 patients that were treated DMH1 purchase for stress urinary incontinence using a tension-free suburethral sling. 50 patients were treated using the retropubic route (SPARC (R)), and 140 patients were treated using a transobturator (MONARC (R)). Results: In total, 16.57% of the patients presented with intraoperative,

immediate postoperative or later postoperative complications. We observed a higher rate of complications with patients who were operated on retropubically (26%) than with patients who were operated on using the transobturator method (12%). Conclusions: The rate of complications for our study was low, and was even lower in the case of transobturator tape. Thus, we usually used transobturator tape in the treatment of stress incontinence. Copyright (C) 2012 S. Karger AG, Basel”
“Streptococcus pneumoniae is a rare cause of sepsis in the newborn.

The term baby was admitted on complaint of dyspnea, and antibiotherapy was begun after samples for hemocultures were obtained with the suspicion of sepsis according to the clinical and laboratory data. S. pneumoniae was demonstrated in the vaginal culture of the mother of the patient whose lumbar punction and chest roentgenogram were normal but hemoculture revealed the propagation of S. pneumoniae. The patient, treated with antibiotherapy for 14 days, was discharged without any complications.

7 +/- 4.8 days. Microbiological eradication was observed in 47 cases (65.3%). Overall mortality was 55.5% and was lower in cases with microbiological eradication vs others (15/47 32% vs 25/25 100%, p<0.0001). Mortality and microbiological eradication rates were not different with monotherapy vs combination therapy (p>0.05). Patients who

died had lower albumin levels, higher APACHE-II scores and CRP levels. The microbiological eradication rate of tigecycline in MDR A. baumannii was considerable. However, eradication of A. baumannii did not result in favorable clinical outcomes in those patients with low albumin, higher APACHE-II scores and CRP levels.”
“The non-structural proteins encoded by the orf-I, II, III, and IV genes of the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) genome, are critical for the modulation of cellular Selleckchem URMC-099 gene AZD2014 molecular weight expression and T-cell proliferation, the escape from cytotoxic T-cells and natural killer cells, and virus expression. In here, we review the main functions of the HTLV-1 orf-I products. The 12 kDa product from orf-I (p12) is proteolytically cleaved within the endoplasmic reticulum (ER) to generate the 8 kDa protein (p8).

At the steady state, both proteins are expressed at similar levels in transfected T-cells. The p12 protein remains in the ER and cis-Golgi, whereas the p8 protein traffics to the cell surface and is recruited to the immunological synapse. The p12 and the p8 proteins have seemingly opposite effects on T-cells; the ER resident p12, modulates T-cell activation and proliferation, whereas p8 induces T-cell anergy. The p8 protein also increases the formation of cellular conduits, is transferred to neighboring T-cells, and increases virus transmission. The requirement for HTLV-1 infectivity of orf-I is demonstrated by the loss of virus infectivity in macaques exposed to an engineered find more virus, whereby expression of orf-I was ablated. Altogether the current knowledge demonstrates that the concerted activity of p8 and

p12 is essential for the persistence of virus infected cells in the host. Published by Elsevier Ltd.”
“Tannic acid cross-linked gelatin-gum arabic coacervate microspheres, capable of sustained release of allyl isothiocyanate (AITC) with high encapsulation efficiency, were developed for safe and efficient oral delivery of AITC. The microspheres were spherical in shape and clustered. Statistical screening and optimization studies revealed that a maximum AITC encapsulation efficiency could be obtained when the microspheres were prepared with 4.5% total biopolymer, 6.5% oil, and 5.9% AITC in oil phase. Release studies showed that the sustained release performance of the optimized microspheres was greatly enhanced by using more tannic acid without loss in the encapsulation efficiency. The microspheres optimized with 1.5% tannic acid, having an encapsulation efficiency of 83.75% and a mean cluster size of 116.

Tour de France of migraine recruited mainly severe migraine sufferers, most of whom had already consulted and were medically followed up. However, migraine management was often suboptimal in these subjects since most of them found their acute treatment of attacks ineffective and only few of them

received a prophylactic treatment. Three months after the conferences, more than half of respondents had consulted for headaches. There was a significant improvement in migraine-related disability, as reflected by a significant decrease in mean Headache Impact Test 6-item score, which might have been related to the higher proportion of subjects receiving a prophylactic treatment of migraine. The Tour de France of migraine campaign revealed the difficulty BMS-777607 clinical trial in sensitizing migraine sufferers towards the necessity of being medically followed up. Mainly patients with severe migraine attended the conferences and derived clinical benefit from the educational program. Other strategies NCT-501 chemical structure should be developed to reach a wider population of migraine sufferers.”
“Drug resistance is a major obstacle for successful treatment of leukemia. Increasing evidence suggests that microRNA-21 (miR-21) is over-expressed in K562/A02 cell line, promoting drug resistance. The

aim of our present study is to investigate the reversal effects of triptolide on drug resistance in adriamycin-resistant cells. Cell viability was measured

by MTT assays and adriamycin induced apoptosis was evaluated by flow cytometry. Levels of miR-21 quantified by real-time PCR. Bcl-2 protein level were measured by western blot. TPL enhanced sensitivity of K562/A02 cells to adriamycin and promoted adriamycin induced apoptosis. Levels of miR-21 and Bcl-2 was significantly decreased after triptolide treatment. Transfection with anti-miR-21, check details a significant up-regulation of sensitivity to adriamycin and a significant down-regulation of Bcl-2 protein level was noted in K562/A02 cells. Our study suggests that triptolide significantly sensitizes K562/A02 cell to adriamycin by inducing apoptosis and these effects of triptolide may be due to its down-regulation of miR-21.”
“Several studies have indicated potential health benefits associated with coffee consumption. These benefits might be ascribed in part to the chlorogenic acids (CGAs), the main (poly)phenols in coffee. The impact of these dietary (poly)phenols on health depends on their bioavailability. As they pass along the gastrointestinal tract, CGAs are metabolized extensively and it is their metabolites rather than the parent compounds that predominate in the circulatory system.

We hypothesized that isoflavone tablets would spare BMD, with biological (age, body weight, serum 25-hydroxyvitamin D) and lifestyle (physical activity, dietary intake) factors modulating BMD loss.

Design: Our double-blind, randomized controlled trial (36 mo) included healthy postmenopausal women (aged 45.8-65.0 y) with intent-to-treat (n = 224) and compliant (n = 208) analyses. Treatment groups consisted of a placebo control group and 2 soy isoflavone groups (80 compared with 120 mg/d); women received 500 mg calcium and 600 IU vitamin D3. Outcomes included

lumbar spine, total proximal femur, Nepicastat datasheet femoral neck, and whole-body BMD.

Results: Analysis of variance for intent-to-treat and compliant (>= 80%) models, respectively, showed no treatment effect for spine (P = 0.46, P = 0.21), femur (P = 0.86, P = 0.46), neck (P = 0.17, P = 0.14), or whole-body (P = 0.86, P = 0.78) BMD. From baseline to 36 mo, BMD declined regardless of treatment. In intent-to-treat and compliant models, respectively, BMD decreases were as follows: spine (-2.08%, -1.99%), femur (-1.43%, -1.38%), neck (-2.56%, -2.51%), and whole body (-1.66%, -1.62%). Regression analysis (compliant model) indicated that age, whole-body fat mass, and bone resorption were common predictors of BMD

change. After adjustment for these factors, 120 mg (compared with placebo) was protective (P = 0.024) for neck BMD. We observed no treatment effect on adverse events, endometrial thickness, or bone markers.

Conclusion: Our results do not show a bone-sparing check details effect of extracted soy isoflavones, except for a modest effect at the femoral neck. This trial was registered at clinicaltrials.gov as NCT00043745. Am J Clin Nutr 2010;91:218-30.”
“Carrier

dynamics of self-assembled InAs quantum dots (QDs) have been investigated by introducing a thin In0.32Ga0.68As layer between InAs QD layer and InAlGaAs layer, which was lattice-matched to an InP substrates. With increasing thickness of In0.32Ga0.68As layer the AG-014699 mouse photoluminescence (PL) emission of the InAs QDs is red-shifted and the PL decay time increases due to increase in QD size and improved QD shape and density. It is found that increases in QD size and/or density lead to a corresponding increase in the PL decay time. (C) 2010 American Institute of Physics. [doi:10.1063/1.3506709]“
“Triple-negative breast cancer (TNBC) is characterized by lack of hormone receptors and HER-2 and shares many features with BRCA1-associated cancer. Preclinical data indicate cisplatin sensitivity, suggesting that these tumors may have defects in the BRCA1 pathway. The carboplatin and gemcitabine (CG) combination is active in unselected anthracycline/taxane pretreated metastatic breast cancer patients, so we carried out a phase II study to evaluate the activity of the CG combination in pretreated metastatic TNBC patients.

Results. The total duration of the procedure took 6 hours, with some complications

related Stem Cell Compound Library clinical trial to frozen armsand robotic arm collision. Even so, there was neither any significant nerve or vessel injury nor peritoneal organ damage. Furthermore, radiologic assessment confirmed proper position of the cage in the center of the disc space.

Conclusion. Use of the da Vinci Surgical System to perform an anterior spinal procedure was shown to be safe and effective in a swine animal model. The utilization of this advanced technology shows promise to reduce the incidence of complications compared with other approaches. It requires further testing in animal models and cadavers, along with serial comparisons to current procedures.”
“Ischemia/reperfusion (I/R) and portal hypertension have been implicated in small-for-size liver graft dysfunction. Matrix metalloproteinases-2 and -9 (MMP-2/9) are critically proposed to involve in hepatic I/R injury and activated by hemodynamic force. We hypothesized that MMP-2/9 overexpression played a crucial role in acute graft injury following small-for-size liver transplantation (LT). Rats were randomly assigned into four groups: 75% partial hepatectomy (PH); 100% LT; 25% LT and 25% LT treated Selleckchem GW4869 with CTT peptide (MMP-2/9 inhibitor). ELISA, real-time PCR, gelatin zymography and immunohistochemistry were used to determine the expression

pattern of MMP-2/9 in liver tissue. MMP-9 expression Selleck SRT2104 was significantly increased 6 h after reperfusion and reached a peak 12 h in the 25% LT group, whereas MMP-2 was expressed in all groups invariably. Compared with the 25% LT group, rats from CTT-treated group exhibited markedly decreased alanine aminotransferase and total bilirubin values, downregulated proinflammatory cytokines, attenuated malondialdehyde (MDA) and myeloperoxidase

(MPO) activities, and improved liver histology. Likewise, MMP-9 inhibition significantly reduced number of TUNEL-positive cells and caspase-3 activity, along with decreased protein levels of Fas and Fas-L. Specifically, rat survival was also improved in the CTT-treated group. These results support critical function of MMP-9 involved in acute small-for-size livergraft injury.”
“Adiposity is a predisposing condition to atherosclerosis, and rheumatoid arthritis (RA) also predisposes to accelerated atherosclerosis. Adiposity is one of the key features of the metabolic syndrome (MetS) and it is well recognised that a metabolic syndrome (and fat tissue) is a major player in this complex network. Endothelial dysfunction and carotid intima-media thickness, early pre-clinical markers of atherosclerosis which are the main determinants of cardiovascular (CV) morbidity and mortality, occur early on in RA. RA patients have an incidence of CV diseases at least two times higher than the general population.

MetS and RA have a low and a severe-moderate degree of inflammation in common, respectively.

065 and 0.31). The subjective knee function 20 years after the injury, according to the five domains of the KOOS score, was good, with a mean score of 90 +/- 11. Values of T1Gd for the medial femoral cartilage were correlated with the KOOS subgroup QOL (P = 0.021,

Pearson correlation).

Conclusions: Subjects who have managed to cope with their ACL injury for 20 years with sustained good subjective knee function also Cyclopamine solubility dmso seem to have knee cartilage of good quality, with T1Gd values not very different from a healthy reference group. (C) 2013 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.”
“Spiranthera odoratissima A. St.-Hil., ‘manaca’, is a medicinal species used in Brazil, especially in central region, for the treatment of several diseases such as pain and inflammation. In this study, the methanol/aqueous phase of the ethanol extract of the leaves of ‘manaca’ Selleckchem PFTα (MAP), at the doses of 50, 150 and 500 mg/kg was used to evaluate the anti-inflammatory and/or antinociceptive effects and the possible anti-inflammatory mechanism.

The antinociceptive and anti-inflammatory activities of MAP were assessed using formalin test, carrageenan-induced paw oedema. The myeloperoxidase activity, capillary permeability, leukocyte migration and tumour necrosis factor alpha (TNF-alpha) levels were evaluated in pleural exudate. The MAP reduced the licking time only in the later phase of formalin test, and showed anti-inflammatory activity by reducing the paw oedema, migration cell, myeloperoxidase activity, capillary permeability and TNF-alpha levels. In conclusion, we confirmed the inflammatory activity of MAP and affirm that this effect involves the reduction of TNF-alpha level.”
“A comparative serologic study was performed in seven single site (SS) farrow-to-finish farms and four multi-site (MS) farrow-to-finish farms, with or

without post-weaning multisystemic wasting syndrome (PMWS). In each farm, 30 blood samples were Z-IETD-FMK price collected for each category of the production cycle: sows, farrowing crate, nursery, grower pigs, and finishing pigs. Sera were evaluated for the presence of antibodies to porcine circovirus type-2 (PCV2) via immunoperoxidase monolayer assay. Serologic profiles for PCV2 were different between SS and MS farms. Seroconversion following the decline in maternal antibodies occurred at a later stage on SS farms (grower pigs) than MS farms (nursery pigs). MS farms tended to have lower antibody titers than SS farms in the categories of sow, piglet, and nursery, while higher antibody titers were found in grower pigs. Characterization of serologic profiles for different farms may provide important information for the adoption of vaccination programs. (C) 2009 Elsevier Ltd. All rights reserved.