(C) 2014 Elsevier Inc. All rights reserved.”
“Gum Cordia based edible films were fabricated as a function of plasticizer type and concentration and their thermal, mechanical and gas permeation were investigated. Solution casting method was adopted for film fabrication. Glycerol, sorbitol, PEG 200 and PEG 400 in the range of 0.1-0.3 g g(-1) dry polymer weight basis were used as plasticizer. Film properties

were found to be dependent on the plasticizer type and concentration. Fourier transform infrared (FTIR) spectroscopy revealed some interaction between plasticizers and the polymer. Differential scanning calorimetry (DSC) supported that plasticizers were miscible with the polymer. The glass transition temperature was found to be between -66 and -11 degrees C. Mechanically, gum Cordia films were found to have good tensile strength selleckchem ( bigger than 10 MPa) and elongation at break ( bigger than 10%). The most pronounced change in tensile property was

exerted by glycerol followed by sorbitol, PEG 200 and PEG 400 respectively. Water vapor permeability was found to be in the range 0.91 -5.5 x 10(-10) g m(-1) s(-1) Pa-1. Oxygen permeability was found to be between 0.16 and 531 x 10(-15) g m(-1) s(-1) pa(-1). (C) 2013 Elsevier Ltd. All rights reserved.”
“A few studies have shown a high prevalence of thyroid autoimmunity GDC-0973 price in patients with psoriatic arthritis. However, thyroid autoimmunity has not been investigated in patients with psoriasis who do not have psoriatic arthritis. We aimed to investigate thyroid autoimmunity in patients with psoriasis. The study included 105 consecutive patients with psoriasis who did not have psoriatic arthritis and a sex and age matching control group consisting of 96 patients with tinea pedis. All of the patients with psoriasis were examined dermatologically and PASI scores were calculated for each patient. Free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), antithyroglobulin (AbTG), and antithyroidperoxidase antibody (AbTPO) levels were measured in all of the subjects. The levels

of TSH, FT3, FT4, AbTG and AbTPO and ultrasonographic findings of thyroid gland were compared statistically between psoriasis and control groups. Also, the levels of TSH, FT3, FT4, AbTG WH-4-023 datasheet and AbTPO of psoriasis patients were compared with PASI scores. Mann-Whitney U test was used as statistical method. The mean age of patients with psoriasis was 40.54 +/- 16.91 years. 56 patients were female, 49 were male. The levels FT4 were found to be significantly increased in the patient group. But levels of AbTPO and AbTG were not statistically different between the two groups. The patients who had thyroiditis plus nodules in thyroid ultrasonography had statistically longer disease periods. This is the first study that investigated autoimmune thyroid disorders in patients with psoriasis who did not have arthritis.

According to cumulative effect analysis of multiple SNPs, patients carrying

4 unfavorable genotypes exhibited more than a 3-fold increased risk of mortality. Finally, both EGF and VEGF expression levels significantly associated with patient mortality. Conclusion: The genetic variants and expression levels of EGF and VEGF can serve as prognostic predictors in patients with advanced ESCC, and thus provide more information for optimizing learn more personalized therapies for patients with ESCC.”
“BACKGROUND The immune checkpoint inhibitor ipilimumab is the standard-of-care treatment for patients with advanced melanoma. Pembrolizumab inhibits the programmed cell death 1 (PD-1) immune checkpoint and has antitumor activity in patients with advanced melanoma. METHODS In this randomized, controlled, phase 3 study, we assigned 834 patients with advanced melanoma

in a 1: 1: 1 ratio to receive pembrolizumab (at a dose of 10 mg per kilogram of body weight) every 2 weeks or every 3 weeks or four doses of ipilimumab (at 3 mg per kilogram) every 3 weeks. Primary end points were progression-free and overall survival. RESULTS The estimated 6-month progression-free-survival rates were 47.3% for pembrolizumab every 2 weeks, 46.4% for pembrolizumab every 3 weeks, and 26.5% for ipilimumab (hazard ratio for disease progression, 0.58; P smaller than 0.001 for both pembrolizumab regimens versus ipilimumab; 95% confidence intervals [CIs], 0.46 to 0.72 and 0.47 to 0.72, respectively). Estimated 12-month survival rates were 74.1%, 68.4%, and 58.2%, respectively (hazard ratio for

death for pembrolizumab Selleckchem GSK690693 every 2 weeks, 0.63; 95% CI, 0.47 to 0.83; P = 0.0005; hazard ratio for pembrolizumab every 3 weeks, 0.69; 95% CI, 0.52 to 0.90; P = 0.0036). The response rate was improved with pembrolizumab administered every 2 weeks (33.7%) and every 3 weeks (32.9%), as compared with ipilimumab (11.9%) (P smaller than 0.001 for both comparisons). Responses were ongoing in https://www.selleckchem.com/products/etomoxir-na-salt.html 89.4%, 96.7%, and 87.9% of patients, respectively, after a median follow-up of 7.9 months. Efficacy was similar in the two pembrolizumab groups. Rates of treatment-related adverse events of grade 3 to 5 severity were lower in the pembrolizumab groups (13.3% and 10.1%) than in the ipilimumab group (19.9%). CONCLUSIONS The anti-PD-1 antibody pembrolizumab prolonged progression-free survival and overall survival and had less high-grade toxicity than did ipilimumab in patients with advanced melanoma.”
“Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a birth incidence of 1/3,500. Around 50% of cases are clue to new Mutations. The NF1 gene maps to 17q11.2 and encodes neurofibromin. NF1 is a “classical” tumor suppressor gene. Congenital disseminated NF1 is rare with just two cases previously reported. We present a deceased baby with congenital disseminated NF1 in whom we performed molecular studies.

\n\nSTUDY DESIGN/SETTING: A prospective cohort study conducted at an academic out patient

clinic.\n\nPATIENT SAMPLE: One hundred forty-one patients undergoing surgery for lumbar or cervical degenerative Autophagy inhibitor supplier conditions.\n\nOUTCOME MEASURES: Self-reported pain and disability were measured with the Brief Pain Inventory and the Oswestry Disability Index/Neck Disability Index, respectively. The physical composite scale of the 12-Item Short-Form Health Survey (SF-12) measured physical health.\n\nMETHODS: Data collection occurred preoperatively and at 6 weeks and 6 months following surgery. Fear of movement was measured with the Tampa Scale for Kinesiophobia and depression with the Prime-MD PHQ-9.\n\nRESULTS: One hundred and twenty patients (85% follow-up) completed the 6-month postoperative assessment. Multivariable mixed-method linear regression analyses found that early postoperative fear of movement (6 weeks) predicted pain intensity, pain interference, disability, and physical health at 6-month follow-up (p<.05). Preoperative and early postoperative depression predicted pain interference, disability, and physical health.\n\nCONCLUSION:

Results provide support for the fear-avoidance model in a postsurgical SBI-0206965 concentration spine population. Early postoperative screening for fear of movement and depressive symptoms that do not acutely improve following surgical intervention appears warranted. Cognitive and behavioral strategies may be beneficial for postsurgical patients with

high fear of movement and/or depressive symptoms. (C) 2014 Elsevier Inc. All rights reserved.”
“ObjectiveTo illustrate the variability in the use of antibiotic prophylaxis for caesarean section, and its effect on the prevention of postoperative infections.\n\nDesignSecondary analysis of a cross-sectional study.\n\nSettingTwenty-nine countries participating in the World Health Organization Multicountry Survey on Maternal and Newborn beta-catenin phosphorylation Health.\n\nPopulationThree hundred and fifty-nine health facilities with the capacity to perform caesarean section.\n\nMethodsDescriptive analysis and effect estimates using multilevel logistic regression.\n\nMain outcome measuresCoverage of antibiotic prophylaxis for caesarean section.\n\nResultsA total of 89 121 caesarean sections were performed in 332 of the 359 facilities included in the survey; 87% under prophylactic antibiotic coverage. Thirty five facilities provided 0-49% coverage and 77 facilities provided 50-89% coverage. Institutional coverage of prophylactic antibiotics varied greatly within most countries, and was related to guideline use and the practice of clinical audits, but not to the size, location of the institution or development index of the country. Mothers with complications, such as HIV infection, anaemia, or pre-eclampsia/eclampsia, were more likely to receive antibiotic prophylaxis.

In this report, we used a unique combination of high-resolution nanoparticle and bulk live imaging approaches to demonstrate that anti-N-methyl-d-aspartate receptor autoantibodies from patients with encephalitis strongly alter, in a time-dependent manner, the surface content and trafficking of GluN2-NMDA receptor subtypes. Autoantibodies laterally displaced surface GluN2A-NMDA receptors out of synapses and completely selleck compound blocked synaptic plasticity.

This loss of extrasynaptic and synaptic N-methyl-d-aspartate receptor is prevented both in vitro and in vivo, by the activation of EPHB2 receptors. Indeed, the anti-N-methyl-d-aspartate receptor autoantibodies weaken the interaction between the extracellular CP-868596 price domains of the N-methyl-d-aspartate and Ephrin-B2 receptors. Together, we demonstrate that the anti-N-methyl-d-aspartate receptor autoantibodies from patients with encephalitis alter the dynamic retention of synaptic N-methyl-d-aspartate receptor through extracellular domain-dependent mechanism(s), shedding new light on the pathology of the neurological and psychiatric disorders observed in these patients and opening possible new therapeutic strategies.”
“PURPOSE. A non-sense mutation at codon 95 in the gene encoding complement factor C9 (C9-R95X) is found most frequently among Japanese. The authors investigated the association between

C9-R95X and Japanese patients with

neovascular age-related macular degeneration (AMD) and polypoidal choroidal vasculopathy (PCV).\n\nMETHODS. The presence of the C9-R95X polymorphism was assessed by direct sequencing in Japanese patients with either PCV (n = 105) or neovascular AMD (n = 198) and 396 control subjects. Multivariate regression analyses were conducted. Photocoagulation was applied in the eyes of mice with a heterozygous defect in the C3 gene and control wild-type mice. Photocoagulation was also applied to wild-type mice before either anti-C9 antibody or isotype IgG was injected into the eyes. The eyes were collected later for measurement of vascular endothelial growth factor (VEGF) and histological Androgen Receptor Antagonist price evaluation of choroidal neovascularization (CNV).\n\nRESULTS. The frequency of those with one or two C9-R95X variants was lower in neovascular AMD (2.02%) than in PCV (5.71%) and controls (6.05%). The presence of C9-R95X conferred a 4.7-fold reduction (95% confidence interval, 1.2-18.1; P = 0.021) in the risk for neovascular AMD after adjusting for the major AMD risk factors. A heterozygous defect in the C3 gene was associated with the reduced growth of laser-induced CNV, as was intraocular injection of anti-C9 antibody. This reduced CNV growth was accompanied by a decreased level of secreted VEGF in the intraocular fluid.\n\nCONCLUSIONS.

\n\nMethod: Serum sex steroid level including E2, estrone (E1) and testosterone (T), of 1402 Chinese men aged : 65 years were analyzed. Genotyping of the two CYP19A1 SNPs was performed using T(m)-shift allele-specific PCR.\n\nResults: SNP rs2899470 was significantly associated with serum E2, El levels and E2/T ratio (p<0.001). However, SNP rs2470152 was only modestly associated with E2/T ratio (p=0.023). Analysis of haplotype showed a significant association between C-G, T-T haplotype with serum E2/T ratio (p=0.019 and p=1 x 10(-5), respectively). Similarly, E2 levels was also associated the T-T and T-G haplotypes (p= 1 x 10(-5)).\n\nConclusion: The genetic variation of CYP19A1

was associated with circulating estrogen levels in Chinese elderly CA4P solubility dmso men. In addition, it revealed that haplotype of rs2899470 and rs2470152, rather than rs2899470 alone, was a better indicator for the serum E2/T ratio and E2 levels. (C) 2009 Elsevier B.V. All rights reserved.”
“Objective: The aims of the present study was to study the significance of ABCB4 mutations in mainland Chinese children with chronic

intrahepatic cholestasis and to correlate genetic findings with clinical features and response to ursodeoxycholic acid (UDCA) therapy.\n\nMethods: Thirteen GW4869 supplier patients with chronic intrahepatic cholestasis and elevated serum gamma-glutamyl transpeptidase activity of unknown cause were enrolled in a single pediatric center. All of the encoding exons and flanking areas of ABCB4 were sequenced.

Available liver biopsy specimens were immunostained for multidrug resistance protein 3. The clinical features, biochemical parameters, selleck chemical and responses to therapy were compared with patients with or without ABCB4 mutation(s).\n\nResults: Six different ABCB4 mutations were identified in 3 patients; each patient was a compound heterozygote. Apart from c. 139C>T (p.R47X), all were novel, including c. 344+2_+3insT, c.1376A>G (p.D459G), c.1745G>A (p.R582Q), c.2077_2078delC (p.P693HfsX698), and c.3825_3826delA (p.M1276WfsX1308). Absent or reduced multidrug resistance protein 3 canalicular immunostaining was demonstrated in patients with ABCB4 mutations. Serum total bile acid levels were higher in patients with ABCB4 mutations than in patients without ABCB4 mutations (352.5 +/- 97.0 vs 55.9 +/- 50.4 mu mol/L, P = 7.32E-05). There was no difference in other biochemical parameters between patients with and without ABCB4 mutations. After oral UDCA administration in 3 patients with ABCB4 mutations, pruritus disappeared, growth improved, spleen size decreased, and platelet counts increased. In the 10 patients without ABCB4 mutations, an inconsistent response to UDCA therapy was observed.\n\nConclusions: In mainland Chinese children, some cases of chronic intrahepatic cholestasis with high gamma-glutamyl transpeptidase could be attributed to ABCB4 mutations.

The recognition maps revealed prominent spots (microdomains) more or less homogeneously distributed on the macrophage surface with the sizes from 4 to 300 nm. Typical recognition image contained about similar to 4% of large clusters (> 200 nm), which were surrounded by a massive CP-456773 cell line number (similar to 50%) of small-size (4-30 nm) and the rest by middle-size (50, 150 nm) domains. These spots were detected from the decrease of oscillation amplitude during specific binding between Fc-coated tip and Fc gamma Rs on macrophage surfaces. In addition, the effect of osmotic swelling on the topographical landscape of macrophage surfaces and on the reorganization of Fc gamma Rs was investigated.”
“LKB1

(also known as serine-threonine kinase 11, STK11) is a tumor suppressor, which is mutated or deleted in LOXO-101 concentration Peutz-Jeghers syndrome (PJS) and in a variety of cancers.

Physiologically, LKB1 possesses multiple cellular functions in the regulation of cell bioenergetics metabolism, cell cycle arrest, embryo development, cell polarity, and apoptosis. New studies demonstrated that LKB1 may also play a role in the maintenance of function and dynamics of hematopoietic stem cells. Over the past years, personalized therapy targeting specific genetic aberrations has attracted intense interests. Within this review, several agents with potential activity against aberrant LKB1 signaling have been discussed. Potential strategies and challenges in targeting LKB1 inactivation are also considered.”
“Objective: To describe and provide preliminary clinical and economic outcomes from a pharmacist-delivered patient-centered health care (PCHC) model implemented in the Mississippi Delta.\n\nSetting: Mississippi between July 2008 and June 2010.\n\nPractice description: 13 community

pharmacies in nine Mississippi Delta counties.\n\nPractice innovation: This PCHC model implements a comprehensive medication therapy management (MTM) program with pharmacist training, individualized patient encounters and Trichostatin A ic50 group education, provider outreach, integration of pharmacists into health information technology, and on-site support in community pharmacies in a medically underserved region with a large burden of chronic disease and health disparities. The program also expands on traditional MTM services through initiatives in health literacy/cultural competency and efforts to increase the provider network and improve access to care.\n\nMain outcome measures: Criteria-based clinical outcomes, quality indicator reports, cost avoidance.\n\nResults: PCHC services have been implemented in 13 pharmacies in nine counties in this underserved region, and 78 pharmacists and 177 students have completed the American Pharmacists Association’s MTM Certificate Training Program.

However, there was no significant difference observed between treated and control groups for apoptosis induction (Bcl-2). Immunohistochemistry, Western blot, and quantitative

polymerase chain reaction results showed both VEGFR-2 and PDGFR-beta expression in the control group was higher than that of the sunitinib-treated group.\n\nConclusion Sunitinib is safe and effective for treating tumors in the course form non-castration to castration groups in LNCaP xenograft prostate tumors. It is potentially beneficial as a prevention and treatment measure for clinical patients with prostate CP-868596 research buy cancer, especially in the course from androgen-dependent prostate cancer to castration-resistant prostate cancer.”
“Since its first description 20 years ago, the tetrazolium-based colorimetric (MTT) assay using MT-4 cells for the detection of anti-HIV compounds has been widely used. This method, which remains popular, provides more information than more recently developed methods and, therefore, Androgen Receptor Antagonist cell line represents a useful methodology on its own or in combination with other screening systems. The replication of HIV in MT-4 cells is usually monitored 5 d after infection; therefore, this protocol can be divided into three steps: the infection (at day 0),

an incubation period (5 d) and the evaluation (at day 5). The long-standing and intensive use of the MTT method has taught users of the limitations and, equally importantly, the unexpected advantages of the MT-4/MTT assay. The use of this method can be extended to antiviral testing of compounds against other cyto-destructive viruses.”
“Alcohol-induced alterations of cerebellar function cause motor coordination impairments that are responsible for

millions of injuries and deaths worldwide. Cognitive deficits associated with alcoholism are also a consequence of cerebellar dysfunction. The mechanisms responsible for these effects of ethanol are poorly understood. Recent studies have identified neurons in the input layer of the cerebellar cortex as important ethanol targets. In this layer, granule cells (GrCs) receive the majority of sensory inputs to the cerebellum through the mossy fibers. Information flow at these neurons www.selleckchem.com/products/ON-01910.html is gated by a specialized pacemaker interneuron known as the Golgi cell, which provides divergent GABAergic input to thousands of GrCs. In vivo electrophysiological experiments have previously shown that acute ethanol exposure abolishes GrC responsiveness to sensory inputs carried by mossy fibers. Slice electrophysiological studies suggest that ethanol causes this effect by potentiating GABAergic transmission at Golgi cell-to-GrC synapses through an increase in Golgi cell excitability. Using patch-clamp electrophysiological techniques in cerebellar slices and computer modeling, we show here that ethanol excites Golgi cells by inhibiting the Na+/K+ ATPase.

Applying a PET-CT scan only in asymptomatic patients is probably as effective and more cost-effective. It is worthwhile to perform additional research to reduce uncertainty regarding the decision concerning imaging in the follow-up of NSCLC. (C) 2009 Elsevier Ltd. All rights reserved.”
“PURPOSE. To collect an entire set of full-length INCB024360 cDNA clones derived from human retina-derived cell lines and to identify full-length transcripts

for retinal preferentially expressed genes.\n\nMETHODS. The full-length cDNA libraries were constructed from a retinoblastoma cell line, Y79, and a retinal pigment epithelium cell line, ARPE-19, using the vector-capping method,

which generates a genuine full-length cDNA. By single-pass sequencing of the 5′-end of cDNA clones and subsequent mapping to the human genome, the authors determined their transcriptional start sites and annotated the cDNA clones.\n\nRESULTS. Of the 23,616 clones isolated from Y79-derived cDNA libraries, 19,229 full-length cDNA clones were identified selleck compound and classified into 4808 genes, including genes of > 10 kbp. Of the 7067 genes obtained from the Y79 and ARPE-19 libraries, the authors selected 72 genes that were preferentially expressed in the eye, of which 131 clones corresponding to 57 genes were fully sequenced.

As a result, we discovered many variants that were produced by different transcriptional start sites, alternative splicing, and alternative polyadenylation.\n\nCONCLUSIONS. The bias-free, full-length cDNA libraries constructed using the vector-capping method were shown to be useful for collecting an entire set of full-length cDNA clones for these retinal cell lines. Full-length transcriptome analysis of these cDNA libraries revealed that there were, unexpectedly, many transcript variants for each gene, indicating that obtaining the full-length cDNA for each variant is indispensable for analyzing its function. The full-length cDNA clones IPI-549 (approximately 80,000 clones each for ARPE-19 and Y79) will be useful as a resource for investigating the human retina. (Invest Ophthalmol Vis Sci. 2011; 52: 6662-6670) DOI: 10.1167/iovs.11-7479″
“Introduction: The English Department of Health introduced universal MRSA screening of admissions to English hospitals in 2010. It commissioned a national audit to review implementation, impact on patient management, admission prevalence and extra yield of MRSA identified compared to “high-risk” specialty or “checklist-activated” screening (CLAS) of patients with MRSA risk factors.\n\nMethods: National audit May 2011.

The primary outcomes are physical activity in the children measured objectively by accelerometry, children’s dietary and physical activity habits measured with a parent-proxy questionnaire and parents’ self-efficacy measured by a questionnaire. Secondary outcomes are height, weight and waist circumference in the children. The duration of the intervention is six months and includes baseline, post intervention and six months follow-up measurements. Linear and logistic regression models will be used to analyse differences

between intervention and control groups in the outcome variables. Mediator and moderator analysis will be performed. Participants Selleckchem BIBF1120 will be interviewed.\n\nDiscussion: The results from this study will show if it is possible to promote a healthy lifestyle and a normal Galardin cell line weight development among children from low-income districts with relatively limited efforts involving parents. Hopefully the study will provide new insights to the further development of effective programmes

to prevent overweight and obesity in children.”
“A fracture of the orbital floor as a result of nose blowing is rare and we know of only three reported cases. We present a 40-year-old man who required repair of a blowout fracture of the orbital floor as a result of vigorous nose blowing. Patients who present with acute periorbital emphysema after nose blowing require careful assessment with potential blowout fractures in mind. Crown Copyright (C) 2010 Published by Elsevier Ltd on behalf of The British Association of Oral and CFTR inhibitor Maxillofacial Surgeons. All rights reserved.”
“Objectives. To evaluate screening patterns within organized cervical screening programs (OCSPs) and survival of women with invasive cervical cancer (ICC).\n\nMethods. A population-based study was conducted in Italian areas covered by cancer registries and OCSPs. The study included all women aged 25-65 years diagnosed with ICC between 1995 and 2008, and their screening

histories within OCSPs were retrieved. Hazard ratios (HR) of death and 95% confidence intervals (Cl) were computed according to screening pattern, using Cox models adjusted for age, ICC stage, and major confounders.\n\nResults. Among 3268 women with ICC, 20% were never-invited to OCSP, 36% were never-compliant with OCSP’s invitation, 33% were compliant and had a screen-detected ICC within OCSP (i.e., after a positive cytology), and 11% were compliant but had a non-screen-detected ICC. Screen-detected ICCs were more frequently micro-invasive (42%) compared to non-screen-detected ones (14%). Compared to women with screen-detected ICC, the adjusted HRs of death were 1.9 (95% Cl 15-2.4) for those never-invited, 2.0 (95% CI 1.6-2.5) for never-compliant, and 1.7 (95% CI 13-2.4) for compliant women having non-screen-detected ICC.\n\nConclusion.

\n\nXanomeline produced rightward shifts in the cocaine dose-effect curve in all three genotypes, but most robustly in wild-type mice. VU0357017 produced rightward shifts in the cocaine dose-effect curve in wild-type selleck compound and M (4) (-/-) mice, but not in M (1) (-/-) mice. Response rates were suppressed by xanomeline in wild-type and M (1) (-/-) but not in M (4) (-/-) mice and were unaltered by VU0357017. 77-LH-28-1

and BQCA also showed evidence of attenuating cocaine’s discriminative stimulus, but at doses that suppressed responding or had other undesirable effects. Intriguingly, both VU0357017 and 77-LH-28-1 exhibited U-shaped dose-effect functions in attenuating cocaine discrimination. None of the drugs substituted for the cocaine stimulus.\n\nAttenuation of the cocaine stimulus by VU0357017 depended upon M-1 receptors, and full effects of xanomeline depended upon both M-1 and M-4 receptors. Therefore M-1-selective agonists and

mixed M-1/M-4 agonists may be promising leads for developing medications that block cocaine’s effects.”
“Hypoplastic glomerulocystic kidney disease is an autosomal dominant disorder caused by mutations in hepatocyte nuclear factor-1 beta. Hepatoblastoma is a sporadic occurring selleck screening library tumor of embryonal origin that has been associated with the several overgrowth syndromes. We report a case of concomitant hypoplastic glomerulocystic kidney disease and hepatoblastoma. Review of the literature identified 4 other patients with a similar association. We propose that hypoplastic glomerulocystic kidney disease and hepatoblastoma

represent a possible association, and we excluded mutations in hepatocyte nuclear factor-1 beta in our patient as causative of this putative association.”
“It find more is widely recognized that as electronic systems’ operating frequency shifts to microwave and millimeter wave bands, the integration of ferrite passive devices with semiconductor solid state active devices holds significant advantages in improved miniaturization, bandwidth, speed, power and production costs, among others. Traditionally, ferrites have been employed in discrete bulk form, despite attempts to integrate ferrite as films within microwave integrated circuits. Technical barriers remain centric to the incompatibility between ferrite and semiconductor materials and their processing protocols. In this review, we present past and present efforts at ferrite integration with semiconductor platforms with the aim to identify the most promising paths to realizing the complete integration of on-chip ferrite and semiconductor devices, assemblies and systems. (C) 2012 American Institute of Physics. [http://0-dx.doi.org.brum.beds.ac.uk/10.1063/1.