Within these mechanisms, modulation of gamma-secretase activity, the activation of the peroxisome proliferator-activated receptor-gamma, binding to prostaglandin receptors or interactions

at the blood-brain barrier may account for the observed protection from AD. This article reviews the current knowledge and views on the above mechanisms and critically discusses current obstacles and the potential as future AD therapeutics.”
“Familial hemiplegic migraine (FHM) is a clinically and genetically small molecule library screening heterogeneous disease most commonly linked to CACNA1A gene mutation Epilepsy rarely occurs in FHM and is seen predominantly with specific CACNA1A gene mutations GNS-1480 Here we report a sporadic case of FHM I linked to S218L CACNA1A gene mutation with the triad of prolonged hemiplegic migraine. cerebellar symptoms, and epileptic seizures Epilepsy in this syndrome follows the pattern of isolated unprovoked seizures occurring only during childhood and hemiplegic migraine-provoked seizures occurring during adulthood Clinical and electrogtophic

status epilepticus can occur during prolonged migraine attacks We suggest that patients with seizures, ataxia, and hemiplegic migraine be genetically tested for FHM Patients with prolonged hemiplegic migraine attacks and confusion should be tested with continuous EEG recording to ascertain whether electrographic status is occurring, as intensive antiepileptic treatment not only resolves status but immediately stops hemiplegic migraine and improves associated neurological Cytoskeletal Signaling inhibitor deficits (C) 2010 Elsevier Inc All rights reserved”
“Gas-liquid interfacial pulse discharge

plasmas are generated in the wide range of gas pressures, where an ionic liquid is used as the liquid electrode. By analyzing the characteristics of discharge voltage and current, the discharge mechanisms at low and high pressures are found to be dominated by secondary electron emission and first Townsend ionization, respectively. Therefore, the discharge properties at low and high pressures are mainly determined by the cathode material and the discharge gas type, respectively. Furthermore, the plasma properties are investigated by a double Langmuir probe. The density of the positive pulse plasma is found to be much smaller than that of the negative pulse plasma, although the discharge voltage and current of the negative and positive pulse plasmas are of the same order of magnitude. The positive pulse discharge plasma is considered to quickly diffuse onto the chamber wall from the radially central region due to its high plasma potential compared with that in the peripheral region. (C) 2010 American Institute of Physics. [doi:10.1063/1.