The SQUID-EPR data show that the EPR linewidth of a concentrated trityl powder decreases dramatically from 4.4 to 1.4 mT as the temperature

is increased from 1.8 to 10 K. The quantitative nature of SQUID-EPR is used to thermodynamically quantify the EPR energy transfer times and saturated fractions. At 95 GHz and 1.8 K, only 40% of the spins are in resonance at the onset of saturation. Conventional dc magnetic susceptibility over 1.8-150 K indicates an S=1/2 Curie-Weiss relationship with little long range interaction. Magnetization versus applied field at 1.8 and 4 K fits a Brillouin function with >80% electronic polarization at a normalized field of g mu(B)mu H-0/kT approximate to 3. These results provide information

required for theoretical modeling and engineering of the trityl radical for a wide range of applications.”
“Background: International ALK inhibitor clinical trial studies suggest that low dose prenatal methylmercury exposure (>29 nmol/L) has long-term adverse neurocognitive effects. There is evidence that the majority of children in Hong Kong exceed this level as a result of high fish consumption of mothers during pregnancy.

Objective: To study whether there are any associations ATM/ATR inhibitor cancer between low-dose prenatal methylmercury exposure and neurocognitive outcomes in Hong Kong children.

Materials and methods: All 1057 children from the original birth cohort were eligible for entry into the study, except children with check details conditions that would affect neurocognitive development, but were unrelated to methylmercury exposure. Subjects were assessed by a wide panel of tests covering a broad range of neurocognitive functions: Hong Kong Wechsler Intelligence Scale for Children (HK-WISC), Hong Kong List Learning Test (HKLLT), Tests of Everyday Attention for Children (TEACH), Boston Naming Test, and Grooved Pegboard Test.

Results: 608 subjects were recruited (median age 8.2 years, IQR 73, 8.8; 53.9% boys). After correction by

con-founders including child age and sex, multivariate analysis showed that cord blood mercury concentration. was significantly associated with three subtests: Picture Arrangement of HK- WISC (coefficient -0.944, P = 0.049) and Short and Long Delay Recall Difference of the HKLLT (coefficient -1.087, P = 0.007 and coefficient -1.161, P = 0.005, respectively), i.e., performance worsened with increasing prenatal methylmercury exposure in these subtests.

Conclusions: Small, but statistically significant adverse associations between prenatal methylmercury exposure and long-term neurocognitive effects (a visual sequencing task and retention ability of verbal memory) were found in our study. These effects are compatible with findings of studies with higher prenatal methylmercury exposure levels and suggest that safe strategies to further reduce exposure levels in Hong Kong are desirable. (C) 2013 Elsevier Ltd. All rights reserved.