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of the human telomerase reverse transcriptase (hTERT) gene transcription: evidence for an endogenous mechanism of transcriptional repression. Mol Biol Cell 2002, 13:2585–2597.PubMedCentralPubMedCrossRef Competing Demeclocycline interests The authors declare that they have no competing interests. Authors’ contributions TFM and CF carried out most of the molecular studies, the statistical analysis, participated in interpretation of data, and were involved in drafting the manuscript. IP, CDJ and JH participated in molecular analysis and interpretation of data. AG, FH and JRJ participated in analysis and interpretation of data, as well as in advice on possible clinical implications of results from this work. MR supplied the PARP3 antibody and the SK-N-SH cells as control for Western-blot. EDR, AJT and MB have been involved in revising the manuscript. PI carried out the design and coordination of the study, and drafted the manuscript. All authors have read and approved the final manuscript.