Additionally, selleck chemical the relationships depicted are referenced; numbers are noted in the figures, and the citations corresponding to the numbers are listed in Supplemental Table S2. Table 2 summarizes the potential effects of these genes on tumorigenesis, based on their connections to the aforementioned processes and their methylation statuses, assuming that methylation changes affect gene expression (e.g., increases in methylation silence expression and decreases in methylation facilitate expression). TABLE 2 Genes Identified from Unique PB-induced RAMs in C3H/He CAR WT (Precancerous Liver and/or Liver Tumor), as compared with Resistant CAR KO Mice, and their Potential Functional Significance in Tumorigenesis FIG. 1. Common targets of genes identified from unique regions of altered DNA methylation (RAMs) in PB-induced precancerous liver tissue from C3H/He CAR WT mice.

An informatic approach was utilized to discern targets of two or more genes identified from unique … FIG. 2. Common targets of genes identified from unique regions of altered DNA methylation (RAMs) in PB-induced liver tumor tissue from C3H/He CAR WT mice. An informatic approach was utilized to discern targets of two or more genes identified from unique PB-induced … FIG. 3. Genes which exhibited altered methylation uniquely in PB-induced precancerous and liver tumor tissue and which are potentially involved in the regulation of angiogenesis. An informatic approach was utilized to discern relationships between angiogenesis … FIG. 4.

Genes which exhibited altered methylation uniquely in PB-induced precancerous and liver tumor tissue and which are potentially involved in the regulation of apoptosis. An informatic approach was utilized to discern relationships between apoptosis and … FIG. 5. Genes which exhibited altered methylation uniquely in PB-induced precancerous and liver tumor tissue and which are potentially involved in the regulation of EMT. An informatic approach was utilized to discern relationships between EMT and unique RAMs … FIG. 6. Genes which exhibited altered methylation uniquely in PB-induced precancerous and liver tumor tissue and which are potentially involved in the regulation of migration, invasion and/or metastasis. An informatic approach was utilized to discern relationships … FIG. 7.

Genes which exhibited altered methylation uniquely in PB-induced precancerous and liver Batimastat tumor tissue and which are potentially involved in the regulation of growth/survival. An informatic approach was utilized to discern relationships between growth/survival … As described in the Methods, unique B6C3F1 RAMs at 2 and 4 weeks (identified in Bachman et al., 2006b; annotated in Phillips and Goodman, 2008), which corresponded to identical genes and uncharacterized genomic regions (i.e.