A total of 2,036 patients (90.7%) underwent MSCT; 1,142 (50.9%) of the patients had one or more incidental findings. A total of 2,844 incidental findings were detected. Overall, 349 tumor findings were noted (12.3% of all incidental findings); 113 findings were suspicious for malignant processes or metastasis. According to our classification, 168 (5.9%) of the incidental findings required urgent follow-up (Level 4), and 527 (18.5%) of the incidental findings required a follow-up before discharge (Level 3).\n\nCONCLUSION: MSCT in patients with multiple injuries reveals one or more incidental findings in more than one

of two patients. A scoring system classifying for relevance of incidental findings was introduced and could be applied in routine trauma care in the future. (J Trauma Acute Care Surg. 2013;75:848-853. Copyright (C) 2013 by Lippincott Williams & Wilkins)”
“Rare Elafibranor copy number variations by the nonrecurrent rearrangements involving PMP22 have been recently suggested to be associated with CMT1A peripheral neuropathy. As a mechanism of the nonrecurrent rearrangement, replication-based fork stalling template switching (FoSTeS) by microhomology-mediated break-induced

replication (MMBIR) has been proposed. We found three Korean CMT1A families with putative nonrecurrent duplication. The duplications were identified by microsatellite typing and

applying a CGH microarray. The breakpoint sequences in two families suggested an Alu-Alu-mediated Selleck Napabucasin rearrangement with the FoSTeS by the MMBIR, and a two-step rearrangement of the replication-based EPZ-6438 ic50 FoSTeS/MMBIR and meiosis-based recombination. The two-step mechanism has still not been reported. Segregation analysis of 17p12 microsatellite markers and breakpoint junction analysis suggested that the nonrecurrent rearrangements are stably inherited without alteration of junction sequence; however, they may allow some alteration of the genomic contents in duplication across generations by recombination event. It might be the first study on the pedigree analysis of the large CMT1A families with nonrecurrent rearrangements. It seems that the exact mechanism of the nonrecurrent rearrangements in the CMT1A may have a far more complex process than has been expected.”
“We address crystalline electric field (CEF) effects in CeT2Al10 (T = Ru, Os) showing novel phase transitions. Because of the absence of inversion symmetry with respect to the b coordinate in the m2m (C-2v) site symmetry for Ce ions, there appears the unfamiliar odd-parity term H-(o) in the CEF, as well as the ordinary even-parity term H-(e). The latter H-(e) is used to determine the local 4f electronic structure consistent with the experimental magnetic susceptibility.