Travelers whose return trip was after April 1, 2011 were not included. All the volunteers were then contacted by phone within 3 weeks after their return, to determine whether they had followed the recommendations regarding vaccinations and antimalarial medications and had respected the physical protection measures against insect bites. Compliance with medical recommendations was considered good when the prescribed vaccination had been given before the trip, and/or when at least 90% of the planned doses of antimalarial chemoprophylaxis had been taken for at least 90% of the planned duration, and/or when the other

means of malaria prevention were applied www.selleckchem.com/products/Everolimus(RAD001).html at least 90% of the time. The questionnaire also sought the reasons for noncompliance for each of these items as well as the occurrence of intercurrent illnesses, drugs taken during the trip, and consultations with physicians upon return. The qualitative variables are presented as frequencies or percentages. Quantitative

variables are presented as means ± SD or medians with extreme values. Categorical variables were compared using the chi-square test, and quantitative variables by Student’s t-test or analysis of variance if normally distributed, or by a nonparametric test or Mann–Whitney test in other cases. Logistic regression analyses were used to identify the variables associated with compliance. Variables with p < 0.2 in the univariate analysis were included in a multivariate FK866 order model, and the selection of independent variables was based on a backward elimination procedure,

retaining those with p ≤ 0.05.The statistical analysis was performed using Statview 5.0. For all tests, the significance level was set at 0.05. Of the 475 people consulted at the ITMS during the study period, 353 (74.3%) agreed to participate in this study. Of these, 336 were successfully 3-mercaptopyruvate sulfurtransferase contacted by phone after their return (95.2%). The main characteristics of these persons are described in Table 1. The majority of trips were for leisure, with a duration of less than 14 days. The travel destinations are detailed in Table 2. Kenya and Senegal accounted for 60% of travelers’ destinations. Most of the travelers were referred to the ITMS by their GPs (43.5%). Travel agencies were responsible for 14.6% of consultations at the ITMS, and 21.7% of the travelers came on their own initiative. The ITMS consultation occurred at least 1 month before the theoretical day of departure for 160 travelers (47.6%), between 15 days and 1 month for 103 travelers (30.7%), between 7 and 14 days for 66 travelers (19.7%), and less than 7 days before the departure for 7 travelers (2%). Fifteen trips had to be canceled. The rest of our study only concerned the 321 travelers who actually made their trip. More than one quarter of these (25.9%, n = 83) used antidiarrheal drugs during their stay.