The majority of respondents of both sexes with migraine endorsed “severe pain” associated with headache. Males with migraine were slightly more likely to endorse “extremely severe pain” whereas females were more likely to endorse “severe pain,” although absolute percentages varied by only 2%. Respondents with PM showed similar results. The majority of females with PM endorsed “moderately severe” pain and the Ensartinib chemical structure majority of males endorsed “severe pain” associated with headache. Males with PM were slightly more likely to endorse

“extremely severe pain” than females although absolute rates were only 2% different (12.8% males vs 10.8% females, female to male PR = 0.84, 95% CI = 0.74-0.95). Females with migraine were 1.34 times more likely than males (12.4% vs 9.3%, 95% CI = 1.21-1.48) to have the highest level of headache-related disability (MIDAS Grade 4) (Table 6). Females were more likely than males to have moderate (PR = 1.46, 95% CI = 1.31-1.63) or mild (PR = 1.46, 95% CI = 1.33-1.60) headache-related disability whereas males were significantly more likely to report no headache-related disability (PR = 0.84, 95% CI = 0.82-0.86). CT99021 in vivo Among those with PM, there was not a significant sex difference among those with severe headache-related disability; however, females with PM were significantly more likely to have moderate

(PR = 1.52, 95% CI = 1.24-1.87) or mild (PR = 1.47, 95% CI = 1.25-1.72) levels of headache-related disability PDK4 than males and were less likely to report no headache-related disability (PR = 0.93, 95% CI = 0.91-0.95). Examination of individual MIDAS items reveal that females with migraine and PM were significantly more

likely than males to report inability to do household work on at least 1 day due to headache, work or school productivity reduced by at least 50% on at least 1 day due to headache, and missed family or social activities on at least 1 day due to headache. When asked how they were usually affected by their “severe” headaches, females with both migraine and PM were significantly more likely than males to report requiring bed rest during an attack, whereas males with migraine and PM were more likely to report being able to work and function normally (Table 6). When asked how long after a headache attack they were unable to work or undertake normal activities, females with migraine were more likely than males to be impaired for 3-<6 days, whereas males with migraine were significantly more likely to report being impaired for 0 or <1 day. Females with PM were significantly more likely than males to be impaired 1-<3 days whereas males with PM were significantly more likely to report no impairment following attacks. Females who met ICHD-2 criteria for migraine at the time of the AMPP Study survey were significantly more likely than males who met these criteria to have been diagnosed with migraine by a HCP (69.8% vs 46.2%; PR = 1.