Successful US avoidance reduces anxiety and thereby reinforces avoidant, behavior. Phobic behavior, then, is a learned avoidance maintained by decreases in anxiety. This formulation is still common among learning theorists and behavior therapists. Certain features of phobias are difficult, to reconcile with such a model. What is the US (the Inhibitors,research,lifescience,medical shock)? Most, phobias do not start with a traumatic incident. Second, why is the range of phobic objects and situations limited? Seligman pointed out that phobias of electric plugs or automobiles should be remarkably common, because many experience shocks

from plugs and have to dodge cars, but in fact, such phobias do not exist. The range of phobic objects is limited, often to phylogenetically significant sources of danger. Classic learning theory, however, has no place Inhibitors,research,lifescience,medical for especially efficacious evolved CSs. Currently, there is debate on whether such stimuli (eg, heights) directly engender fear or facilitate conditioning. Further, from a simple Inhibitors,research,lifescience,medical conditioning viewpoint, patients should learn to avoid stimuli that occur regularly before anxiety onset, but this is not. usual. Patients often avoid situations in which they would feel helpless if

panic or the phobic stimulus occurred, even if they never experienced panic there, eg, tunnels Inhibitors,research,lifescience,medical or bridges. Situations, such as high grass, where snakes or insects might surprisingly appear, are shunned by these specific phobies, even if this experience has never occurred. Unmodified learning theory is insufficient as a theory of anxiety, since it does not explain how phobias start, ie, the nature of the US, does not account for the limited variety of phobic stimuli, and gives the wrong predictors for the spread of avoidances. It is consonant only with the therapeutic efficacy of certain deconditioning procedures, but. useless in explaining the equivalent effectiveness of alternative procedures that appear to work against deconditioning. Inhibitors,research,lifescience,medical The equation of such animal behaviors with human neurosis raised many hackles regarding

anthropomorphism and oversimplification. However, animal models are used in a thriving industry to (occasionally) discover humanly useful antianxiety Brefeldin_A agents. Many different procedures have been developed that nominally induce anxious sellckchem anticipation and behavioral defenses against differing dangers. Remarkably, the intercorrelation of the effects of differing procedures is usually almost, zero. This questions the presumption that “anxiety” Gemcitabine synthesis univocally refers to a single adaptive function. If neurosis is learned, why is it. not spontaneously unlearned or extinguished? CRs extinguish when CSs fail to predict USs.This became known as the “neurotic paradox” and received many explanations.