Similar mechanisms may be involved in toxicities observed in clinical trials of gamma-secretase inhibitors. A model of allelic interference may explain the dominant negative transmission of neurotoxic loss of function in FAD neurodegeneration. (C) 2013
S. Karger AG, Basel”
“The effect of folic acid Mizoribine and folic acid + vitamin B-12 supplementation upon short-term arsenic-induced systemic and pancreatic islet cell mitochondria oxidative stress was investigated in male rats. Arsenic trioxide was administered orally at a dose of 3 mg kg body weight(-1) day(-1) for 30 days, and folic acid and vitamin B-12 were administered at a dose of 36 and 0.63 mu g kg body weight(-1) day(-1), respectively, for 30 days. Compared to control, arsenic-treated group showed a significant increase in the levels of systemic oxidative GSK3326595 markers, malondialdehyde (MDA), nitric oxide (NO), and hydroxyl radical (OH-) formation, which were found decreased significantly after supplementation either with folic acid or a combination of folic acid + vitamin B-12. Similar supplementations were found effective against arsenic-induced oxidative marker changes (MDA, NO, and OH-) in pancreatic islet cell mitochondria. Also, low activities of antioxidant defense enzymes such
as superoxide dismutase and catalase, and level of antioxidant glutathione, all could regain significantly on supplementations both against systemic and islet cell mitochondria oxidative stress. Results of agarose-gel electrophoresis of DNA from lymphocytes and islet cells of arsenic-exposed rats showed DNA smearing, which could be reduced with simultaneous administration either with
folic acid or a combination of folic acid + vitamin B-12. Significantly, similar supplementations were found effective in increasing the urinary clearance of arsenic. Together, these results indicate that folic acid and vitamin B-12 may be effective to reduce the arsenic-induced damage at molecular target level. (c) 2008 Wiley Periodicals, A-1210477 order Inc. Environ Toxicol 24: 377-387, 2009.”
“Rationale and aim: Injuries due to the accidental ingestion or aspiration of small parts have became a matter of interest in the last 30 years, focusing on the relationship between a proper prevention and the diminished frequency of occurrences. Small parts in commonly used objects represent a large sector of potential danger, taking explicit mouthing behavior of children in the first four years of life. In this paper the intent is to show the current situation of design projects and legislation around the world, meant to avoid the casual accidents due to manufacturing reasons. Proposed process and quality control standards seek to eliminate production errors and control materials to avoid deviation from the design.