One four-arm trial (Itoh et al 2007) compared traditional Chinese acupuncture with acupuncture directed at ‘trigger points’, acupuncture directed to regions adjacent to ‘trigger points’, and sham acupuncture. The three acupuncture groups in this trial were combined to create a single pair-wise comparison. Pooled outcomes

from five trials (Itoh et al 2007, Nabeta and Kawakita 2002, Petrie and inhibitors Hazleman 1986, Vas et al 2006, White et al 2004) showed no significant difference in pain outcomes between acupuncture and control at the conclusion of a course of treatment (WMD –12, 95% CI –23 to 0.1). Pooled results from the three trials (Petrie and Hazleman 1986, Vas et al 2006, White et al 2004) that reported

medium-term pain outcomes showed acupuncture to be no more Navitoclax purchase effective learn more than control (WMD –4, 95% CI –15 to 7), consistent with the single trial (White et al 2004) that reported long-term pain outcomes (MD –4, 95% CI –13 to 7). Pooled outcomes from five trials (Itoh et al 2007, Petrie and Hazleman 1986, Vas et al 2006, White et al 2004, Witt et al 2006) showed a significant but small difference in disability outcomes in favour of acupuncture at the conclusion of treatment (WMD –8, 95% CI –13 to –2). Pooled outcomes from the three trials (Petrie and Hazleman 1986, White et al 2004, Witt et al 2006) that reported medium-term disability outcomes 4-Aminobutyrate aminotransferase demonstrated that acupuncture was not more effective than control (WMD –1, 95% CI –2 to 0.3), consistent with the single trial (White et al 2004) that reported long-term disability outcomes (MD –4, 95% CI –10 to 2). Exercise: Five trials investigated exercise for non-specific neck pain. One three-arm trial ( Kjellman and Oberg 2002)

compared McKenzie exercise with general exercise and with sham ultrasound. Four trials compared various exercise approaches with minimal intervention. The exercise approaches included ‘proprioceptive’ exercises ( Revel et al 1994), a combined program of neck stabilisation, relaxation, eye fixation, behavioural support, and posture training ( Taimela et al 2000), group gymnastic exercises ( Takala et al 1994), and muscle strengthening ( Viljanen et al 2003). Pooled outcomes from three trials (Kjellman and Oberg 2002, Revel et al 1994, Taimela et al 2000) showed significant reduction in pain at the conclusion of a course of specific exercises (WMD –12, 95% CI –22 to –2). The single trial that reported medium- (MD –6, 95% CI –17 to 5) and long-term (MD 1, 95% CI –12 to 14) pain outcomes for specific exercise programs did not demonstrate similar benefit (Kjellman and Oberg 2002). One trial (Kjellman and Oberg 2002) showed no significant difference in disability at the conclusion of a course of specific exercises (MD –3, 95% CI –10 to 4) and medium- (MD –3, 95% CI –11 to 5) and long-term (MD 2, 95% CI –6 to 10) follow-up.