involving the aorta are associated with high rates of morbidity and mortality, JQ1 and their management is complex. Saturating Dacron grafts in rifampin (60 mg/mL) inhibits the growth of organisms commonly found to be involved in both primary aortic infections and aortoenteric fistulas. Open repair and replacement of the aorta with rifampin-soaked Dacron grafts is frequently used in clinical practice and is considered a viable option for open repair with a low recurrence of infection; however, the morbidity and mortality of the procedure is significant. More recently, patients who are high risk for open surgery have been managed with endografts to treat infected aortas and aortoenteric fistulas with limited success, a high recurrence rate, and elevated mortality. We describe a technique to expose Dacron endografts with rifampin delivered via injection port or into the sheath before deployment in selected patients with aortic infections. We used this novel technique in 2 patients who were high risk for open repair: 1 with a bleeding aortoenteric fistula and 1 with mycotic abdominal aortic aneurysm. The first patient tolerated 1.5 years without surgical correction of the duodenal defect after placement
of a rifampin-treated endograft. This allowed her to recover and ultimately undergo definitive repair under elective circumstances. Our second patient remains without evidence of recurrence 1 year after implantation MK-2206 cost for a mycotic abdominal aortic aneurysm. Following the principles of rifampin use in open vascular repairs, treating Dacron endografts with rifampin may add similar antimicrobial resistance when used to treat selected aortic infections.”
“Calcium phosphate coating was fabricated by in situ laser cladding using mixed powders selleck kinase inhibitor of CaCO3 and CaHPO4, which presented a complex phase constitution since the reactions between CaCO3 and CaHPO4 would produce not only hydroxyapatite (HA) in the coating, but also other phases, such as Ca-4(PO4)(2)O (TTCP) and alpha-Ca-3(PO4)(2) (alpha-TCP). In order to realize the control of the phase constitution, the effects of the Ca/P molar ratio of mixed powders, laser power, scanning velocity and heat treatment on
the phase constitution of the coatings were investigated through X-ray diffraction analysis. It is found that the variation of the Ca/P molar ratio of the mixed powders, laser power and scanning velocity can adjust, to a certain extent, the proportion of HA, alpha-TCP, and TTCP in the coating. However, the alpha-TCP and TTCP cannot be eliminated from the coating due to the intrinsic high cooling rate of the laser melt pool during laser cladding. By suitable post heat treatment, the TTCP and alpha-TCP in the coating can be partially or completely transformed into HA. Therefore, HA coating or coatings with desirable proportion of HA, alpha-TCP and TTCP can be obtained by in situ laser cladding plus post heat treatment. (c) 2012 Elsevier B.V. All rights reserved.