G(i) inactivator (pertussis toxin) lowered TPVR but not in all SHR. Delta TPVR induced by alpha 1-adrenoceptor agonist (phenylephrine) was reduced by 8CPT-cAMP and milrinone in both strains. They also clearly reduced the response to endogenous noradrenaline release (tyramine) in SHR but had little effect in WKY. When pertussis toxin reduced baseline, it also eliminated the
tyramine TPVR response. Propranolol did not change the effect of milrinone on the phenylephrine or tyramine response. Strain-related differences in aorta, femoral arteries or skeletal muscle PDE activity (total/PDE3/PDE4) were absent. Conclusions: cAMP signaling down-stream of cAMP was functional in SHR, and opposed alpha 1-adrenoceptor vasoconstriction in both strains. G(i) activity greatly influenced the MX69 order TPVR baseline and adrenergic TPVR responses, and its activity appeared increased in SHR. Therapeutics aiming to increase signaling through this pathway may turn out to be valuable in the treatment of hypertension. Copyright (C) 2008 S. Karger AG, Basel”
“Autism is a neurodevelopmental disorder
characterized by disorders in social interaction and emotional reciprocity which can be explained by impairments of the ability to understand the mental states of others (“”theory of mind”") and recognition of facial expressions. These impairments may be related to the difficulties with face recognition characteristic of this disorder. Face perception find more plays a critical role in the development of social interaction and understanding of the internal emotional state of others. It depends on initial oculomotor exploration. The aim of DOK2 this study was to quantify ocular behaviour in 11 adults with autism and 23 healthy subjects (15-35 years) while exploring neutral faces and faces expressing an emotion using an eye tracking method. The strategy used to explore faces was also studied. All subjects spent significantly
more time on the eye region than on the rest of the face. However, subjects with autism spent less time on the eye region than healthy subjects. The latter used a strategy based on their own eye dominance when exploring faces. All healthy subjects significantly began their exploration of a face by looking at the eye in the contralateral visual field to their dominant eye. This strategy seemed to be impaired in patients with autism. To conclude, these results contrast with earlier reports regarding the lack of interest in the eye region in patients with autism, and demonstrate for the first time that perception of the face is dependent on eye dominance. (c) 2008 Elsevier Ltd. All rights reserved.”
“This study investigated the effects of 7-ketocholesterol on interleukin (IL)-6 expression in vascular smooth muscle cells (VSMC). Among the 7 IL examined, only IL-6 transcript was increased by 7-ketocholesterol treatment in human aorta smooth muscle cells.