Current research on biodegradable polymers is emerging, combining these structures with osteogenic cells, as an alternative to autologous bone grafts. Different types of biodegradable materials have been proposed for the preparation of three-dimensional
porous scaffolds for bone tissue engineering. Among them, natural polymers are one of the most attractive options, mainly due to their similarities with extracellular matrix, chemical versatility, good biological performance, and inherent cellular interactions. In this review, special HDAC inhibitor attention is given to chitosan as a biomaterial for bone tissue engineering applications. An extensive literature survey was performed on the preparation of chitosan scaffolds and their in vitro biological performance as well as their potential to facilitate in vivo bone regeneration. The present review also aims to offer the reader a general overview of all components needed to engineer new bone tissue. It gives a brief background on bone biology, followed by an explanation of all components in bone tissue
engineering, as well as describing different tissue engineering strategies. Moreover, also discussed are the typical models used to evaluate in vitro functionality of a tissue-engineered construct and in vivo models to assess the potential to regenerate bone tissue are discussed.”
“Study Design. A prospective diagnostic learn more clinical trial.
Objective. To evaluate the accuracy, repeatability of a new method for measuring spinal curvature in patients with scoliosis, the axis-line-distance technique (ALDT), in comparison with the Cobb method.
Summary of
Background Data. Timely and accurate determination of the degree of lateral curvature of the spine is essential for deciding the appropriate treatment method for scoliosis. Although the Cobb method has been accepted as the Napabucasin research buy clinical standard for 60 years, many investigators have reported a high degree of variance in the measurements of spinal curvature obtained using this method. Therefore, the development of an alternative method that incorporates the advances in imaging technology and assessment is needed.
Methods. Sixty-five scoliosis patients were evaluated by 6 physician observers. The spinal curves were measured on 2 separate occasions using the Cobb method and the ALDT on a picture archiving and communication system workstation. The time interval between the 2 measurements was 3 weeks, and the data were analyzed by a paired-sample Student t test and Pearson correlation method using SPSS 12.0 software package.
Results. Intraobserver variance of the 2 measurements, the minimum variance, the maximum variance, and the mean and standard deviation values were 0, 26, and 5.14 degrees +/- 0.69 degrees for the Cobb method, and 0 mm, 20 mm, and 2.55 +/- 0.38 mm for the ALDT, respectively.