At the univariate analysis, age (p <

0.0001), Okuda stage (p = 0.046) (Figure 5), type of TACE (P < 0,0001) and number of TACE treatments (p = 0.003) were found to be prognostic factors influencing overall survival. Type of TACE (p = 0.0003) and the number of TACE treatments (p = 0.004) were also found to be prognostic factors influencing the time to progression. Figure 5 Median overall survival for Apoptosis Compound Library screening global patients population according to the Okuda staging system: Okuda 1(—), Okuda 2 (———) and Okuda 3 (………)

(33 vs 29 vs 14 months, p = 0.046). CA3 ic50 At multivariate analysis, age, the Okuda stage, type of TACE and number of TACE treatments proved to be independent prognostic factors influencing overall survival (p < 0.0001). Only type and number of TACE treatments proved to be independent prognostic factors influencing time to progression (p < 0.0001). Overall response rate for patients treated with lipiodol TACE or pTACE respectively was: complete response in 17 (20%) and 14 (24%) patients, partial remission ADAMTS5 in 32 (39%) GSK872 solubility dmso and 19

(33%) patients, stable disease in 16 (19%) and 7 (12%) patients, and progressive disease in 18 (22%) and 18 (31%) patients. No statistically significant differences in terms of objective response (assessed according to RECIST criteria) was found between the groups of patients treated with lipiodol TACE or pTACE with microspheres (Table 3). Table 3 Response rate observed in the global case series and according to treatment received (lipiodol TACE or pTACE) (CR = complete remission; PR = partial remission; SD = stable disease; PD = progressive disease NA = not available) Objective response     TACE lipiodol pTACE microspheres Total CR (%) 17 (20) 14 (24) 31 (22) PR (%) 32 (39) 19 (33) 51 (36) SD (%) 16 (19) 7 (12) 23 (15) PD (%) 18 (22) 18 (31) 36 (27) NA 8 1 9 The toxicity profiles (were not statistically different between the groups of patients treated with lipiodol TACE or pTACE (Table 4). Table 4 Main toxicity results for lipiodol TACE and pTACE according to NCI-CTC 3.0 (National Cancer Institute – Common Toxicity Criteria 3.0).