Association between adult body weight and +2138InsCAGACC, another variant in the 3′ untranslated region of MC3R, has also been described.
Objective: The objective of this study was to examine associations of C17A + G241A
and + 2138InsCAGACC MC3R variants with children’s energy balance.
Design: Children aged 6-19 y were genotyped for MC3R C17A, G241A, HSP990 supplier and + 2138InsCAGACC. Subjects underwent studies of energy intake from a 9835-kcal food array (n = 185), resting energy expenditure (REE) by using indirect calorimetry (n = 302), or total daily energy expenditure (TEE) by using doubly labeled water (n = 120). Linear regression was used to examine the associations between MC3R polymorphisms and the measures of energy balance.
Results: Body mass index and fat mass were greater in those with double homozygosity for C17A + G241A (P = 0.001). After accounting for covariates (including body composition), the number of minor C17A + G241A alleles was associated with significantly greater energy intake (beta = +0.15, P = 0.02) but not altered REE or TEE. No significant associations were observed between Tyrosine Kinase Inhibitor Library in vitro + 2138InsCAGACC and measures
of either fat mass or energy balance.
Conclusions: C17A + G241A polymorphisms may be associated with pediatric obesity because of greater energy intake rather than because of diminished energy expenditure. + 2138InsCAGACC does not appear to be associated with obesity or measures of energy balance in children. Am J Clin Nutr 2009; 90: 912-20.”
“We assessed a sample of unselected adult asylum seekers to determine their
current mental health status and patterns of healthcare utilisation.
METHOD: We included 78 unselected adult asylum seekers after their first year of residence in the Zurich area of Switzerland. The Swiss Federal Office for Migration provided their names and addresses. The current mental health of the participants was assessed through diagnostic interviews. Their use of healthcare services and the resultant costs over a 12-month period were established by reference to the records of the responsible health insurance company.
RESULTS: Forty-one percent of participants had at least one psychiatric disorder, primarily major depression and posttraumatic stress disorder. Healthcare costs were about 1.8 Selleck Etomoxir times those of the average resident population. Asylum seekers sought medical advice more than twice as often as did average residents. While they presented high psychiatric morbidity, they received very little specific treatment.
CONCLUSION: Asylum seekers incur higher healthcare costs than comparable residents. Mentally ill asylum seekers are underdiagnosed and often inadequately treated.”
“S45A, a double recessive mutant at both the BnMs1 and BnMs2 loci in Brassica napus, produces no pollen in mature anthers and no seeds by self-fertilization.