74 ± 0.40 3.03 ± 0.351 10.5 6.757 p < 0.001 0.775 VCO 2 [L/min]

3.08 ± 0.47 3.73 ± 0.518 21.1 5.594 p < 0.001 1.319 VE [L/min] 84.60 ± 17.74 116.80 ± 22.44 38 4.790 p < 0.001 1.592 RR 39.26 ± 9.24 50.53 ± 7.33 28.7 5.683 p < 0.001 1.352 PETO 2 [mmHg] 88.87 ± 4.19 96.25 ± 4.02 8.3 5.869 p < 0.001 1.798 PETCO 2 [mmHg] BIBW2992 40.86 ± 4.28 35.16 ± 3.78 −16.2 7.270 p < 0.001 1.412 DFCO 2 /DFO 2 1.109 ± 0.053 1.233 ± 0.072 7.4 4.233 p < 0.005 1.962 RER 1.147 ± 0.052 1.247 ± 0.066 8.7 3.873 p < 0.005 1.690 VO 2 /Kg [ml/kg/min] 39.25 ± 3.69 43.63 ± 3.78 11.1 5.912 p < 0.001 1.174 VCO 2 /Kg [ml/kg/min] 44.95 ± 4.61 54.29 ± 6.45 20.7 4.769 p < 0.005 1.666 VE/Kg [ml/kg/min] 1229.9 ± 212.13 1692.6 ± 296.5 37.6 4.306 p < 0.005 1.795 EQO 2 30.60 ± 4.65 38.80 ± 4.13 26.7 4.984 p < 0.001 1.865 EQCO 2 26.20 ± 3.65 31.20 ± 2.78 19 6.578 p < 0.001 1.542 VT [L] 2.165 ± 0.489 2.536 ± 0.404 17.1 6.770 p < 0.001 0.827 VA [L] 86.00 ± 19.22 117.31 ± 22.22 36.4 4.492 p < 0.005 1.507 METS 11.21 ± 1.06 12.48 ± 1.07 11.3 6.054 p < 0.001 1.192 EE [kcal/h] 847.60 ± 123.64 955.10 ± 116.98 12.6 6.138 p < 0.001 0.893 FETO 2 [%] 14.95 ± 0.70 16.35 ± 0.55 9.3 6.917 p < 0.001 2.232 FETCO 2 [%] 6.681 ± 0.679 5.800 ± 0.507 −15.1 6.102 p < 0.001 1.470 CHO [kcal/h] 1276.7 ± 232.39 1721.4 ± 327.85 34.8 4.170 p < 0.005 1.565 FAT [kcal/h] 323.38 ± 124.04 691.06 ± 223.77 13.6 4.834 p < 0.001 2.032 Data

are expressed as mean ± SD. Functional parameters significantly improved in post-test Anacetrapib as compared with pre-test. A substantial increase Rabusertib in vivo in the respiratory ventilation, respiratory rate (RR), VO2/Kg, VCO2/Kg, MET, and energy expenditure were observed showing enhancement in the respiratory efficiency and energy expenditure during the exercise. An increase in the breathing rate, normally

leads to a lower alveolar and arterial PCO2 and therefore, decrease in the end-tidal carbon dioxide tension (PETCO2) and fractional end-tidal CO2 concentration (FETCO2) expected (Table 1). Time to exhaustion, vertical distance, horizontal distance, maximum work, and power compared and presented in the Table 2. Table 2 Changes in the exercise performance parameters Parameter Pre-test (n = 12) Post-test (n = 12) Changes% T P value Effect size Horizontal distance (m) 843.5 ± 234.6 1187.6 ± 309.2 40.7 6.890 p < 0.001 1.254 Vertical distance (m) 113.4 ± 40.09 172.8 ± 59.41 52.3 6.262 p < 0.001 1.173 Work (KJ) 78.34 ± 32.84 118.7 ± 47.38 51.5 5.746 p < 0.001 0.992 Power (KW) 114.3 ± 24.24 139.4 ± 27.80 21.9 6.764 p < 0.001 0.962 Time to exhaustion (S) 664.5 ± 114.2 830.2 ± 129.8 24.9 7.255 p < 0.001 1.355 Data are expressed as mean ± SD. Functional indicators of exercise performance showed significant increase in the time to exhaustion and distance (Table 2). In the Tables 3 and 4, the lung function indicators and other physiological parameters compared between pre-test and post-test.