52,5% 122 113 107 110 93 94 95 89 −4.3 AZD5363 concentration (−7.1; -1.4) Qs     97 69 70 87 78 142 144 175 +13.5 (10.2; 17.0) P. di Trento Ms 80,9% 79,2% 115 127 129 128 146 135 119 134 +1.2 (−1.5; +3.9) Qs     136 175 166 216 208 236 209 251 +9.4 (7.5; 11.4) Veneto Ms 76,8% 77,1% 1512 1475 1457 1267 1200 1312 1305 1406 −1.8 (−2.6; -1.0) Qs     1510 1612 1588 1674 1595 1893 2075 2296 +14.7 (13.8; 15.6) Friuli Venezia AZD6244 solubility dmso Giulia Ms 98,7% 62,6% 539 550 571 529 529 534 545 527 −0.5 (−1.8; 0.8) Qs     533 526 563 606 710 930 809 798 +8.2 (6.9; 9.4) Liguria Ms

34,4% 66,9% 405 393 402 376 420 350 301 334 −3.4 (−4.9; -1.8) Qs     809 847 893 1.010 993 1.063 1049 1077 +6.2 (5.1; 7.3) Emilia Romagna Ms 96,0% 72,4% 1530 buy Tucidinostat 1542 1382 1372 1200 1253 1274 1262 −3.3 (−4.1; -2.5) Qs     2061 2169 2148 2.378 2644 2690 2666 2927 +5.2 (4.6; 5.8) Total Northern Italy Ms 82,0% 67,9% 9,170 8,914 8,507 8,155 7,701 7,692 7,561 7,870 −2.7 (−3.0; -2.4) Qs     13,139 13,638 13,634 14,567 15,100 16,103 16,421 17,186 +3.3 (3.0; 3.5) Toscana Ms 86,4% 69,5% 968 994 841 853 796 814 845 782 −3.0 (−4.0; 2.0) Qs     1661 1859 1871

2055 1960 2037 2010 2022 +2.3 (1.6; 3.0) Umbria Ms 89,0% 73,3% 249 197 195 216 190 179 161 209 −3.1 (−5.1; -1.0) Qs     443 429 453 436 471 501 482 550 +3.1 (1.6; 4.5) Marche Ms 74,2% 54,2% 485 515 483 486 472 413 371 378 −4.4 (−5.7; -3.0) Qs     482 537 536 587 653 678 731 753 +6.7 (5.4; 8.0) Lazio Ms 63,6% 47,6% 1516 1652 1456 1489 1405 1382 1325 1368 −2.4 (−3.2; -1.6) Qs     2.222 2376 2581 2771 2950 2759 2849 3330 +4.9 (4.2; 5.5) Abruzzo Ms 56,6% 50,5% 267

270 206 225 Tangeritin 219 187 217 236 −2.8 (−4.7; -0.8)       381 375 310 376 332 386 424 421 +2.3 (0.7; 3.9) Total Central Italy Ms 78,5% 59,7% 3,485 3,628 3,181 3,269 3,082 2,975 2,919 2,973 −2.9 (−3.4; -2.4) Qs     5,189 5,576 5,751 6,225 6,366 6,361 6,496 7,076 +3.9 (3.5; 4.3) Molise Ms 48,5% 43,4% 62 55 83 74 69 63 76 47 −1.2 (−4.8; +2.6) Qs     46 70 83 117 103 115 95 121 +9.8 (6.4; 13.4) Campania Ms 50,0% 29,6% 897 909 950 968 878 786 813 797 −2.4 (−3.4; -1.4) Qs     1.194 1271 1323 1429 1495 1568 1687 1885 +6.4 (5.6; 7.3) Puglia Ms 25,3% 33,4% 987 928 903 933 901 963 959 1051 +0.9 (0.0; 1.9) Qs     1.010 1174 1182 1315 1324 1361 1410 1520 +12.8 (11.7; 13.8) Basilicata Ms 100,0% 49,2% 88 98 78 75 89 110 107 114 +4.3 (1.1; 7.6) Qs     81 59 92 97 99 110 112 135 +8.9 (5.6; 12.3) Calabria Ms 51,8% 26,2% 295 322 320 287 237 239 245 221 −5.1 (−6.9; -3.4) Qs     195 225 233 302 355 380 362 434 +11.7 (9.8; 13.7) Sicilia Ms 49,2% 41,7% 770 911 856 743 724 719 654 696 −3.4 (−4.5; -2.4) Qs     1.286 1476 1616 1542 1691 1819 1765 1846 +4.6 (3.8; 5.4) Sardegna Ms 57,2% 54,1% – - 448 416 432 408 398 428 −1.1 (−3.4; +1.1) Qs     – - 429 514 451 486 611 597 +6.7 (4.5; 8.9) Total Southern Italy Ms 46,5% 36,3% 3,099 3,223 3,638 3,496 3,330 3,288 3,252 3,354 +0.3 (−0.3; +0.8) Qs     3,812 4,275 4,958 5,316 5,518 5,839 6,042 6,538 +7.2 (6.8; 7.