3%, ICC = 0.993) and ventricular components (95% CI +/- 6.6%, ICC = 0.989). Inter- observer 95% limits of agreement were within +/- 10.7% (ICC = 0.979), 7.4% (ICC = 0.991) and 7.2% (ICC = 0.991) for atrial, ventricular and total pericardial adipose tissue, respectively.
Conclusion: This study validates the use of a semi-automated three dimensional atrial PAT model utilizing standard (clinical) CMR sequences for accurate and reproducible assessment of atrial PAT. The measurement of local cardiac fat stores via this methodology could provide a sensitive tool to examine the regional effect of fat deposition on atrial substrate which potentially may influence AF ablation strategies
in obese patients.”
“The study was conducted to rind out whether the bioavailability of a 500 mg azithromycin (CAS 83905-01-5) Selleck 3-MA tablet (Zycin (R), test) was equivalent to that of a reference formulation. The pharmacokinetic
parameters assessed in this study were the area under the plasma concentration-time curve from time zero to 120 h (AUC(t)), area under the plasma concentration-time curve from time zero to infinity (AUC(Inf)), the peak plasma concentration of the drug (C(max)), time needed to achieve the peak plasma concentration (t(max)), and the elimination half-life https://www.selleckchem.com/products/pf299804.html (t(1/2)).
This was a randomized, single blind, two-period, cross-over study which included 18 healthy adult male and female subjects under fasting conditions. In each of the two study periods (separated by a washout of two weeks) a single dose of test or reference drug was administered. Blood samples were taken up to 120 It post dose, the plasma was separated and the concentrations of azithromycin were determined by a LC-MS/MS method.
In this study, the mean AUC(t), AUC(inf), C(max) and t(1/2) of azithromycin from the test drug were 4967.49 ng . h . mL(-1), 5871.74 ng . h . mL(-1), 412.14 ng/mL,
and 51.32 h, respectively. The mean AUC(t), AUC(t), AUC(inf), C(max), and t(1/2) of azithromycin from the reference drug were 4276.75 ng . h mL(-1), 5578.12 ng . h . mL(-1), 419.89 ng/mL, and 51.23 h, respectively. The median t(max) of he test drug and reference drug were 3.0 h and 2.0 h, respectively. The geometric mean ratios (90 % CI) of the test drug/reference drug for azithromycin were Selleck LY3023414 101.56 % (86.61 -119.08 %) for AUC(t), 101.27 % (84.97 -120.70 %) for AUCInf, and 97.78 % (84.50 -113.16%) for C(max).
Based on this study, it was concluded that the two azithromycin tablets (test and reference drug) were bioequivalent in terms of the rate and extent of absorption.”
“In the context of inter subject brain surface matching, we present a parameterization of the cortical surface constrained by a model of cortical organization. The parameterization is defined via an harmonic mapping of each hemisphere surface to a rectangular planar domain that integrates a representation of the model.