2 +/- 17.3 mg/kg/day). Efficacy was assessed by seizure frequency evaluated by comparison with baseline frequency. Tolerability was evaluated by analysis of parental report of adverse events and laboratory tests. Responders were defined as patients who achieved a 50% or greater decrease in countable seizures
this website within 18 months of initiating RUF therapy.
Results: Mean overall duration of RUF treatment was 14.5 months (range: 3-18 months). Retention rate, defined as the percentage of patients still taking RUF after 18 months, was 41.7% (n = 25/60). The overall response rate after 18 months was 26.7% (16/60 patients). The highest response rates were found in the subgroup of patients with Lennox-Gastaut syndrome (LGS, 35.5%) and in patients with other generalized epilepsy syndromes. Complete seizure control was maintained in one patient (1.6%). A total of 73 adverse events were reported in 37 of 60 patients. The most frequently occurring adverse events were fatigue (18.3%), vomiting (15.0%), and loss of appetite (10.0%). Only 4 new adverse events were reported after week 12. No serious adverse events were observed.
Conclusions: The present data suggest that β-Nicotinamide RUF is efficacious and well tolerated in the long-term treatment of children and adults with various epilepsy syndromes and difficult-to-control
seizures. (C) 2010 Elsevier Inc. All rights reserved.”
“In this article, we present an investigation of the structural development of poly(ethylene terephthalate) (PET) during uniaxial stretching above the glass-transition temperature; this followed a statistical design of experiment approach to determine the influence of the stretching variables on the structural development. Amorphous PET was submitted to a stretching program with variations in the stretching temperature (T(st)), stretching rate ((epsilon) over dot(st)), and stretching ratio (lambda(st)). Stretched samples were rapidly quenched and characterized
by wide-angle X-ray scattering, optical birefringence, and differential scanning calorimetry. The relevance and influence of the stretching variables on the obtained parameters (phase fraction, phase orientation, and thermal parameters) were analyzed. The strain-induced crystallinity check details was controlled by T(st), lambda(st), and the interactions between them. Mesophase development was not dependant on T(st) but on the interactions between (epsilon) over dot(st) and lambda(st). The molecular orientation was proportionally dependent on T(st), lambda(st), and their interactions. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 120: 1253-1265, 2011″
“A novel sensitive molecularly imprinted electrochemical sensor has been developed for selective detection of tyramine by combination of multiwalled carbon nanotube-gold nanoparticle (MWCNT-AuNP) composites and chitosan. MWCNT-AuNP composites were introduced for the enhancement of electronic transmission and sensitivity.