1) and dried for 24 h at room temperature. The shape of the crystals was observed under optical microscope (10 magnification) attached to computer. It is the density of the actual solid material. This was determined by liquid displacement method by using 25 cc specific gravity bottle with toluene as immersion fluid. Three replicate determinations were made and the mean calculated. It is defined as the mass of

a powder divided by the bulk volume. This was determined by the following method.17 A sample of 25.0 cc of powder from SCR7 each batch, which has been previously lightly shaken in a closed container to break any agglomerates formed, was introduced into a 100 ml graduated cylinder. The cylinder was then dropped at 2-s intervals onto a hard wood surface three times from a height of 1 inch. Thus, bulk density was

obtained by dividing the weight of the sample in grams by the final volume in cc of the sample contained in the cylinder. Three replicate determinations were made and the mean calculated (Remi Motors, Bombay, India). It is defined as the mass of a powder divided by the tap volume. A loosely packed volume of 25 cc of the powder GSK1120212 supplier from each batch was poured in a measuring cylinder by means of a funnel, after shaking lightly in a closed container. After observing the initial volume, the cylinder was mechanically raised and allowed to fall under its own weight on a hard surface from a height of 2.5 cm at the rate of 120 taps per minute, until no further change in the volume was observed. The tap density was calculated by dividing the weight of the sample in grams by the final volume in c.c. of the sample contained in the

cylinder. Three replicate determinations were made and mean calculated (Remi Motors, Bombay, India). Carr derived18 this dimensionless quantity 17-DMAG (Alvespimycin) HCl which proves to be useful to the same degree as that of angle of repose values for predicting the flow behavior and compressibility behavior. Compressibility indirectly gives an excellent picture of uniformity in size and shape, cohesion and moisture content. The formula used was, CI=[(Tappeddensity−Bulkdensity)/Tappeddensity]×100 The computed values for the different batches of crystals were expressed in percent. Particles with high interparticulate friction or cohesiveness have Hausner ratio greater than 1.6 and % compressibility values higher than 40, whereas powder with Hausner ratio less than 1.2 and % compressibility between 5 and 17 can be classified as free flowing powders.19 Hausner ratio was calculated using following formula. Hausner’sRatio=Tappeddensity/Bulkdensity The state of packing of a powder is described by its porosity, which is defined as the ratio of the void volume to the bulk volume of the packing. Porosity=[Bulkvolume−Tappedvolume/Bulkvolume]×100 Angle of repose was determined for all the batches as an index of flow behavior using basically, the method suggested by Pilpel.