05 ☨ Statistically

different between Spring 2009 and Spring 2010 at p < .05 P20 LACK OF OSTEOPOROSIS TREATMENT IN REAL WORLD HIP FRACTURE PATIENTS Kelly Krohn, MD, Lilly USA, Indianapolis, IN PURPOSE: National Osteoporosis Foundation guidelines recommend that postmenopausal individuals age 50 and older presenting with hip fracture should be considered for treatment Temsirolimus solubility dmso with pharmacologic osteoporosis (OP) treatment. This study examined patterns of OP treatment strategies among hip fracture (HFx) patients in real world clinical practice. METHODS: Patients aged 50+ with an HFx between 1/1/2002 and 12/31/2010 (first observed HFx = index) were identified from a large U.S. administrative claims database. Patients included for study had 6+ months of pre-index continuous enrollment (baseline), no baseline evidence of teriparatide (TPTD), cancer, or Paget’s disease. Patients were followed for up-to 36 months post-index to observe patterns in pharmacologic OP treatment strategies. Five cohorts were constructed based on pre- and post-index use of OP treatment: patients with no observed evidence of OP treatment pre- or post-index (N/N); new bisphosphonate (BP)

initiators with no baseline BP (N/BP); BP continuers with baseline BP (BP/BP); new TPTD initiators with no baseline BP treatment (N/TPTD); TPTD initiators switching from prior BP (BP/TPTD). Demographics, clinical characteristics, Selleck LY2603618 and healthcare resource use were compared across the 5 cohorts. RESULTS: Study included 71,115 patients. The majority of the sample, 53,634 (75 % of total) patients, was

observed to have no OP treatment (N/N) over a median of 352 days of follow-up; 26,238 of whom had ≥1 year of follow-up. New BP initiators (N/BP; 9,187 patients) started BP treatment within a median of 117 days. BP continuers (BP/BP; 7,463 patients) resumed treatment within a median of 58 days. New TPTD initiators (N/TPTD; 346 patients) started TPTD treatment within a median of 138 days. TPTD initiators switching from prior BP (BP/TPTD; 485 patients) selleck kinase inhibitor switched to TPTD treatment within a median of 64 days. DCLK1 Mean ages ranged from 74.0 (BP/TPTD) to 80.5 (N/N) years. The N/N cohort was the oldest (81 vs. 74–79 years), had the highest proportion of males (39 % vs. 8–18 %), and the lowest baseline use rates of systemic glucocorticoids (13 % vs. 17–30 %) and dual energy X-ray absorptiometry scans (2 % vs. 5–17 %). CONCLUSIONS: In spite of a sentinel event of a hip fracture, which is a known risk factor for future fracture, 75 % of patients had no evidence of OP treatment over a median follow-up of 352 days. These data provide further evidence of a substantial gap in the management of OP among patients at very high risk for fractures.