Based on our own results and previous

work, we posit that a decrease in MBP expression and/or an increase in MAG expression might contribute to impaired motor BMS-777607 manufacturer function and neuronal regeneration in mTBI patients. From these preliminary studies, we also hypothesize that M2 proteomics can reveal subtler changes in CSP expression than those observed herein, such as those reflecting long-term secondary effects on motor impairment and unit integrity, as well as underlying molecular mechanisms, at 180 days post-injury and beyond. For these reasons and others, M2 proteomics is expected to become increasingly important to accurately predict clinical outcome and improve risk group stratification and therapy for mTBI patients. We acknowledge the RCMI and RTRN grants from the National Institute on Minority Health and Health Disparities (G12MD007591 and U54MD008149, respectively) for funding (Haskins WE). This research was funded in part by an independent National Research Service Award, National Institute for Neurological Diseases and Stroke (1F31NS080508-01; Evans TM) and the Hartford

Foundation/American Federation for Aging Research Scholars in Geriatric Medicine Program (Jaramillo CA). We would also like to acknowledge the support of the Sam and Ann Barshop institute for Longevity and Aging Studies. Lastly, we thank the dedicated patients, physicians Selleckchem Temsirolimus and researchers in the TBI community for their strong support of protein biomarker research for

TBI. The authors have no conflicts of interest to report. “
“As Tyrosine-protein kinase BLK we celebrate the start of 2013, I am pleased to announce the first publications in our newly launched journal, Translational Proteomics. This has been made possible thanks to Elsevier’s strong support and the enthusiastic participation of the Journal’s Associate Editors and Editorial Board members. Over the years, the difficulties of transferring fundamental proteomics discoveries to clinical applications have caused a lot of frustration to proteomics researchers and clinicians alike, in both academia and industry. One of the reasons for this barrier is the lack of understanding between basic scientists and physicians: they have been trained using opposing concepts. Whilst the former want to control and understand all variables, the latter need rapid actions on patients, rather than absolute certainties. Both disciplines are difficult to condense into a single scientist and therefore interdisciplinary associations need to be fostered. Translational research has often been viewed as a two-way street: bedside to bench, and back to bedside.