An involvement of 44d was also reported for the processing of complex sentences in other studies (Friederici et al., 2006 and Grewe et al., 2005). The pars triangularis within Broca’s area, which was subdivided into a more posterior part (45p) and a more anterior part (45a) (Amunts et al., 2010), is involved in processing semantic aspects both at the word (Fiez, 1997, Heim et al., 2009 and Thompson-Schill et al., 1997) and sentence levels (Newman, Ikuta, & Burns, 2010) as well Omipalisib mouse as for sentence comprehension in general (Saur et al., 2008). The posterior superior temporal gyrus and sulcus (pSTG/STS) play a significant role in sentence processing (Friederici, Makuuchi, & Bahlmann,

2009), and in the brain-based decoding of human voice and speech (Formisano, De Martino, Bonte, & Goebel, 2008). These different regions of the inferior frontal and temporal cortex are known to be structurally connected by short-range connections (Makuuchi et al., 2009 and Upadhyay et al., 2008) and by long-range fiber bundles (Catani et al., 2005, Ganetespib solubility dmso Friederici et al., 2006 and Saur et al., 2008). Thereby the different areas constitute a large-scale

fronto-temporal language network for sentence comprehension (Friederici, 2009 and Friederici, 2011). Neurotransmitters and their receptors are key molecules of neuronal function. Within a given brain region, different receptor types are expressed at largely varying densities.

Thus, the balance between the densities of different receptors in a single brain region, and not the mere presence or absence of a single receptor type, results in a regional specific receptor pattern, i.e., a “receptor fingerprint” (Zilles et al., 2002). Consequently, receptor fingerprints represent the molecular default 4��8C organization of the regionally specific local information processing in each cortical area. Differences between the fingerprints of unimodal sensory, motor, and multimodal association areas of the human cerebral cortex (Caspers et al., 2013a, Eickhoff et al., 2008 and Zilles et al., 2004) underlined the regional diversity of multireceptor expression levels. E.g., cortical areas belonging either to the dorsal or ventral visual streams have similar fingerprints within each of the streams, but differ between streams (Eickhoff et al., 2008). Connectionally distinct areas within inferior parietal lobule (IPL) also differ in their receptor fingerprints (Caspers, Schleicher, et al., 2013). Since the cortical areas of the dorsal or ventral streams, as well as those of the inferior parietal cortex are immediate neighbors, it could be argued, that the similarities in receptor fingerprints resulted merely from the close spatial relation of areas within each of the three regions, and not from their common affiliation to a given functional system.