[33] Pit and fissure sealant This sealant can be produced from a composition comprising a polymerizable resin system containing acrylic monomer and at least one colorant selected from the group selleck compound consisting of annatto extract, turmeric extract, and ��-Apo-8��-Carotenal.[2] Anticancer properties Curcumin has been found to possess anticancer activities because of its effect on a variety of biological pathways involved in mutagenesis, oncogene expression, cell cycle regulation, apoptosis, tumorigenesis, and metastasis. It potentiates the effect of chemotherapy and acts as an enhancer of radiotherapy. Also, it is found to arrest carcinomatous cells in the G2/M phase of cell cycle, in which cells are more susceptible to cytotoxic effects of radiotherapy.

[34] Precancerous lesions Its role in the treatment of various precancerous conditions like oral submucous fibrosis, leukoplakia, and lichen planus has also been studied. Turmeric extract and turmeric oil have demonstrated oncopreventive activity in in vitro and in vivo animal experiments. The local symptoms of burning sensation and pain were reduced and partial reversal of opening of the mouth was also observed.[35] Adverse effects Generally considered safe, but may cause gastric irritation, stomach upset, nausea, diarrhoea, allergic skin reaction, and antithrombosis activity interfering with blood-clot formation. Future challenges One of the major concerns with developing curcumin for clinical efficacy is its low oral bioavailability that can be attributed to its poor absorption, high rate of metabolism in the intestines, and rapid elimination from the body.

Also, little information is available to determine its safety in higher doses. Nanotechnology-based novel strategies are being aggressively explored worldwide to enhance curcumin’s bioavailability and reduce perceived toxicity.[36] CONCLUSION Turmeric is considered a safe, nontoxic, and effective alternative for many conventional drugs due to its distinguished therapeutic properties and multiple effects on various systems of the body. Its role in the treatment of cancers is very promising. However, there is scarcity of information and research in this field. Therefore, further research is required to determine the optimal dosage, bioavailability, and bio-efficacy of curcumin-based drugs. Dacomitinib Footnotes Source of Support: Nil Conflict of Interest: None declared
Sir, There have been several recent articles focusing on the Greek crisis and its effects on the Hellenic public health system[1�C3] or on the quality of the healthcare provided.