Cox proportional hazard modeling
NSC23766 clinical trial indicated older age (hazard ratio [HR], 1.04), CHF (HR, 2.26), and RF (HR, 2.60) were risk factors for decreased survival. Factors associated with SES were not significantly related to the outcomes.
Conclusions: This study found that RU is high for amputees, and increased RU persists beyond the perioperative period. Results were similar across SES indices, suggesting higher SES may not be protective against poor outcomes when limb salvage is no longer attainable. These findings support the hypothesis that SES disparities may be more modifiable during earlier stages of care for critical limb ischemia. (J Vasc Surg 2013;57:784-90.)”
“Acute coronary syndromes (ACS) are associated with platelet activation. The aim of the present study was to study the protein expression level associated JQ-EZ-05 nmr with glycolysis, oxidative stress, cytoskeleton and cell survival in platelets obtained during an ACS. Platelets from 42
coronary ischemic patients, divided into patients admitted within 24 h after the onset of chest pain (ACS group; n = 16) and patients with stable coronary ischemic disease (CAD, n = 26), were analyzed using proteomics. The expression levels of proteins involved in cellular cytoskeleton (F-actin capping, beta-tubulin, alpha-tubulin isotypes 1 and 2, vinculin, vimentin and two Ras-related protein Rab-7b isotypes), glycolysis pathway (glyceraldehyde-3-phosphate dehydrogenase, lactate dehydrogenase and two pyruvate kinase isotypes) and cellular-related because antioxidant system (manganese superoxide dismutase) and even the expression and activity of glutathione-S-transferase were significantly reduced in platelets from ACS patients compared to CAD patients. Moreover, reduction in the expression of proteins associated with cell survival
such as proteasome subunit beta type 1 was also observed in ACS platelets compared with CAD platelets. Principal component and logistic regression analysis suggested the existence of factors (proteins) expressed in the platelets inversely associated with acute coronary ischemia. In summary, these results suggest the existence of circulating antioxidant, cytoskeleton and glycolytic-”"bewildered” platelets during the acute phase of a coronary event.”
“Objective: Groin wound infection is an important cause of postoperative morbidity in vascular surgery patients, especially when prosthetic grafts are involved. The objective of this study was to investigate if Prevena (Kinetic Concepts, Inc, San Antonio, Tex), a negative pressure incision management system, could reduce the risk of groin wound infection in patients after vascular surgery.
Methods: Ninety patients (115 groin incisions) underwent longitudinal or transverse femoral cutdown for vascular procedures.