As a physiological index for evaluating the effects of dental treatment, the usefulness of encephalic waves has been suggested GDC-0199 ic50 [15]. When neuronal function in the cerebral cortex is absent due to Alzheimer-type dementia, the electrical potential

distribution is distorted. Therefore, Hara et al. [16] established the diagnosis method of neuronal dysfunction (DIMENSION), which quantitatively estimates synaptic neuronal function in the brain using electroencephalographs (EEG). EEG can be used to instantly record brain waves through the head skin using electrodes. Musha et al. [17] reported that DIMENSION could distinguish between Alzheimer-type dementia patients and healthy individuals, and that there were strong correlations between DIMENSION and brain blood flow measurement IOX1 results obtained using single photon emission computed tomography (SPECT), which is applied for the diagnosis of dementia, and the results of patient interviews (Mini-Mental State Examination). Jelic and Kowalski [18] reported that evidence for the diagnostic utility of resting EEG in dementia and mild cognitive impairment is still insufficient to establish this method for the initial evaluation of subjects with cognitive impairment in routine clinical practice. Indeed, MRI shows high-level diagnostic accuracy in Alzheimer’s disease, dementia, and cognitive impairment, and

is frequently used for a differential diagnosis in these diseases [19], [20], [21] and [22]. However, several reports described abnormal brain waves in Alzheimer’s disease patients using EEG analysis [23], [24], [25], [26] and [27]. The purpose of this study was not to diagnose dementia, but evaluate brain function activity using EEG. In this research, it was necessary to measure in a short time brain function of denture wearers who sought denture treatment at the prosthodontic clinic. Also, they had no suspected brain disease. MRI can only be used in facilities, which have the required equipment. MRI measurement is necessary 10 or 20 times compared

with EEG Rebamipide measurement. Furthermore, to estimate the brain function activity before and after denture treatment or before and after gum chewing, we need to catch dynamic changes in brain function activity. EEG can perform dynamic measurement, but MRI cannot. The advantages of EEG are as follows: (1) EEG measurements are possible at prosthodontic clinics which have the device. (2) EEG measurements can be performed in a short time, so changes in the brain activity before and after denture treatment or before and after gum chewing can be measured easily. (3) Dynamic EEG can be measured. (4) EEG can be measured without damaging the living body such as through radiation or a strong magnetic field. (5) The EEG system is relatively inexpensive. Considering the above merits, brain function activities are evaluated by DIMENSION analysis using EEG data [28] and [29].