15 Consequently, the ongoing phase III efficacy trial with this strain is conducted with higher dose (105 ffu) and a 3-dose schedule (6, 10 and 14 weeks).15 It can be argued that one study in South Africa and Malawi with monovalent rotavirus vaccine (RV1, marketed as Rotarix) did not detect significant differences in vaccine immunogenicity or efficacy on pooled analysis between the cohort receiving two vaccine doses and the cohort receiving three doses.3 However, there was a slight but

non-significant trend toward higher seroconversion rates and vaccine efficacy with the three-dose schedule, and these differences were more marked in South Africa (81.5 (55.1–93.7) vs 72.2 (40.4–88.3)) than in Malawi (49.7 (11.3–72.2) this website vs 49.2 (11.1–71.7)).3 The two-dose schedule used in this trial was 10 and 14 weeks instead of 6 and 10 weeks.3 Administering rotavirus vaccines at younger ages could further lower the immunogenicity of the vaccines, because of the potential for greater interference of maternal antibody and enhanced replication of the oral poliovirus vaccine.3 In the above African

study with RV1, the researchers accepted that the study was not powered to detect differences in dose schedule.3 Furthermore, there have been low seroconversion rates (58.3%; 95% CI: 48.7; 67.4) with two doses of RV1 in comparison Amisulpride with three-dose schedule of RV5 (82.4% (CI; 75; 90%)) and 116E (89.7% (42.4; 80.6%)) in immunogenicity studies in India.15, 16 and 17 In the click here RV1 trial, the first dose was administered between 8 and 10 weeks (mean age – 8.7 weeks)

and the second dose between 12 and 16 weeks (mean age – 13.4 weeks).16 Hence, there is no immunogenicity data for 6 and 10 weeks administration or data on interference with simultaneous OPV administration from India. It is important when examining immunogenicity data to point out that although seroconversion is not a direct proxy for efficacy, it does demonstrate that the virus is able to colonize the infant gut and induce a robust immune response. Figure options Download full-size image Download as PowerPoint slide According to the WHO Ad-hoc Group of Experts on rotavirus vaccines,18 most countries with high rotavirus disease incidence or high under-5 mortality rates (where children would particularly benefit from robust protection from rotavirus infection) have 6, 10, 14 week EPI schedules. If rotavirus vaccines are to be co-administered with OPV in a setting with an EPI vaccination schedule beginning at 6 weeks of age, the second dose of RV1 may not be sufficient to provide adequate immunity against severe rotavirus disease.